AZD6738

Ligand id: 9390

Name: AZD6738

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 116.23
Molecular weight 412.17
XLogP 2.37
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Database Links
PubChem CID 54761306
Search Google for chemical match using the InChIKey OHUHVTCQTUDPIJ-JYCIKRDWSA-N
Search Google for chemicals with the same backbone OHUHVTCQTUDPIJ
Search UniChem for chemical match using the InChIKey OHUHVTCQTUDPIJ-JYCIKRDWSA-N
Search UniChem for chemicals with the same backbone OHUHVTCQTUDPIJ
Comments
AZD6738 is an orally available small molecule inhibitor of ATR serine/threonine kinase [1]. AZD6738 induces cell death and senescence in cancer cells in vitro and enhances the therapeutic efficacy of cisplatin in xenograft models. In vivo, combining AZD6738 with cisplatin destroys ATM-deficient lung cancer xenografts.