AZD7986

Ligand id: 9412

Name: AZD7986

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 103.69
Molecular weight 420.18
XLogP 3.83
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
(2S)-N-[(1S)-1-cyano-2-[4-(3-methyl-2-oxo-1,3-benzoxazol-5-yl)phenyl]ethyl]-1,4-oxazepane-2-carboxamide
Synonyms
compound 30 [1]
Database Links
PubChem CID 118253852
Search Google for chemical match using the InChIKey AEXFXNFMSAAELR-RXVVDRJESA-N
Search Google for chemicals with the same backbone AEXFXNFMSAAELR
Search UniChem for chemical match using the InChIKey AEXFXNFMSAAELR-RXVVDRJESA-N
Search UniChem for chemicals with the same backbone AEXFXNFMSAAELR
Comments
AZD7986 is reported as a second generation, irreversible inhibitor of dipeptidyl peptidase 1 (DPP1; a.k.a. cathepsin C) [1]. Cathepsin C is required for the activation of proinflammatory neutrophil serine proteases, making this enzyme a drug target whose pharmacological inhibition has potential in the treatment of diseases such as chronic obstructive pulmonary disease (COPD) which is driven in part by excessive neutrophil activation and dysregulated neutrophil elastase activity.