liver enriched antimicrobial peptide 2   Click here for help

GtoPdb Ligand ID: 9734

Abbreviated name: LEAP2
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: LEAP2 is an endogenous peptide with antimicrobial properties, that is part of the humoral immune response to microbes. It is expressed in the liver. LEAP2 has also been identified as an endogenous antagonist of the appetite-stimulatory hormone, ghrelin, that is secreted in the stomach and which acts via the pituitary/hypothalamic ghrelin receptor (growth hormone secretagogue receptor, or GHSR) [1].
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
LEAP2 liver enriched antimicrobial peptide 2 Human liver-expressed antimicrobial peptide 2 precursor LEAP-2, liver expressed antimicrobial peptide 2
Database Links Click here for help
Specialist databases
GPCRdb Ligand liver enriched antimicrobial peptide 2
Other databases
Ensembl Gene ENSG00000164406 (Hs)
GtoPdb PubChem SID 354702210
Human Protein Atlas ENSG00000164406 (Hs)
UniProtKB Q969E1 (Hs)