The IUPHAR Guide to PHARMACOLOGY complete ligand list

Peptides encoded in the human, rat and mouse genomes.

A  B  C  D  E  F  G  H  I  K  L  M  N  O  P  Q  R  S  T  U  V  W  X 

Ligand name ID Synonyms
A Back to top
ACTH  {Sp: Human} 3633 Acthar®, adrenocorticotropic hormone (1-39), corticotropin
ACTH  {Sp: Mouse, Rat} 1331 ACTH (1-39), adrenocorticotrophin, adrenocorticotropic hormone (1-39), corticotropin
activin A  {Sp: Human} 4857
activin AB  {Sp: Human} 4858
activin B  {Sp: Human} 4859
adiponectin  {Sp: Human} 3726 flAdipo
ADP-ribosylation factor 1  {Sp: Human} 5305 Arf1, ARF-1
adrenomedullin  {Sp: Human} 683 AM
adrenomedullin  {Sp: Mouse} 3589 AM, mouse adrenomedullin
adrenomedullin  {Sp: Rat} 697 AM
adrenomedullin 2/intermedin  {Sp: Human} 684 AM2/IMD
adrenomedullin 2/intermedin  {Sp: Mouse} 3590
adrenomedullin 2/intermedin  {Sp: Rat} 3591
adropin  {Sp: Human} 9573
agouti  {Sp: Human} 3609
agouti  {Sp: Mouse} 1329 ASIP
agouti  {Sp: Rat} 3610
agouti-related protein  {Sp: Human} 1335 AGRP, agouti-related peptide
agouti-related protein  {Sp: Mouse} 3611 AGRP, agouti-related peptide
agrin  {Sp: Human} 5319
alamandine  {Sp: Human, Mouse, Rat} 6065
alarin  {Sp: Rat} 6123
amphiregulin  {Sp: Human} 4864 colorectal cell-derived growth factor (CRDGF)
amylin  {Sp: Human} 687 AMY
amylin  {Sp: Mouse, Rat} 688 AMY
amyloid β  {Sp: Human} 4865 amyloid β-peptide, beta-amyloid protein
angiopoietin-1  {Sp: Human} 4867 ANG-1
angiopoietin-2  {Sp: Human} 5316 ANG-2
angiopoietin-4  {Sp: Human} 4868 ANG-4
angiopoietin-like 3  {Sp: Human} 8716 ANGPTL3
angiopoietin protein-like 1  {Sp: Human} 5317 ANG-3, angiopoietin 3, angiopoietin-like protein 1
angiopoietin-related protein 7  {Sp: Human} 5321 ANGPTL7, angiopoietin-like factor, angiopoietin-like protein 7, AngX, CDT6, cornea-derived transcript 6 protein
angiotensin-(1-7)  {Sp: Human, Mouse, Rat} 582 ang 1-7, angiotensin 1-7
angiotensin-(1-9)  {Sp: Human, Mouse, Rat} 5138 ang 1-9, angiotensin 1-9
angiotensin A  {Sp: Human} 6894 ang A
angiotensin I  {Sp: Human, Mouse, Rat} 583 ang I
angiotensin II  {Sp: Human, Mouse, Rat} 2504 ang II
angiotensin III  {Sp: Human, Mouse, Rat} 585 ang III
angiotensin IV  {Sp: Human, Mouse, Rat} 5368 AT II (3-8)
annexin I  {Sp: Human} 1031 ANXA1, annexin 1, annexin A1
annexin I-(2-26)  {Sp: Human} 1044 annexin I, Ac2-26, annexin-derived peptide, ANXA1-derived peptide
annexin I  {Sp: Mouse} 3568
annexin I  {Sp: Rat} 3569
apelin-36  {Sp: Human} 606
apelin-13  {Sp: Human, Mouse, Rat} 605 [Pyr1]-Apelin-13
apelin-17  {Sp: Human, Mouse, Rat} 3556 K17F
apelin-36  {Sp: Mouse, Rat} 3555
apelin receptor early endogenous ligand  {Sp: Human} 7930 ELA, ELABELA, Ende, tdl, toddler
apelin receptor early endogenous ligand  {Sp: Mouse} 7931 Ende
APRIL  {Sp: Human} 5068 A proliferation-inducing ligand, TALL2, TNF- and APOL-related leukocyte expressed ligand 2, TNF-related death ligand 1, TRDL-1, ZTNF2
artemin  {Sp: Human} 4871 ARTN
asprosin  {Sp: Human} 9200
atrial natriuretic peptide  {Sp: Human} 4869 ANP, atrial natriuretic factor (ANF)
 
B Back to top
BAFF  {Sp: Human} 5069 B cell-activating factor, CD257 antigen, dendritic cell-derived TNF-like molecule
B and T lymphocyte attenuator  {Sp: Human} 4891 BTLA, B- and T-lymphocyte attenuator , B- and T-lymphocyte-associated protein
4-1BB ligand  {Sp: Human} 5081 CDw137L
BDNF  {Sp: Human} 4872
bestrophin-3  {Sp: Human} 5377 vitelliform macular dystrophy 2-like protein 3
betacellulin  {Sp: Human} 4873
beta-defensin 4A  {Sp: Human} 3648 beta-defensin 2, HBD2, skin-antimicrobial peptide 1 (SAP1)
BH3 interacting-domain death agonist  {Sp: Human} 5152 BID
big dynorphin  {Sp: Human, Mouse, Rat} 3669 big dyn
BigLEN  {Sp: Mouse} 6704 b-LEN, Big LEN, SAAS CT(25-40)
BMP-10  {Sp: Human} 4875
BMP-15  {Sp: Human} 4880 GDF-9B, growth/differentiation factor 9B
BMP-2  {Sp: Human} 4881 BMP-2A, bone morphogenetic protein 2A
BMP-3  {Sp: Human} 4882 BMP-3A, bone morphogenetic protein 3A
BMP-4  {Sp: Human} 4883 BMP-2B, bone morphogenetic protein 2B
BMP-5  {Sp: Human} 4884
BMP-6  {Sp: Human} 4885 VG-1-R, VG-1-related protein, VGR-1
BMP-7  {Sp: Human} 4886
BMP-9  {Sp: Human} 4889 bone morphogenetic protein 9, GDF-2
BMP-8A  {Sp: Human} 4887 bone morphogenetic protein 8A
BMP-8B  {Sp: Human} 4888 BMP-8
bovine adrenal medulla peptide 8-22  {Sp: Human} 4058 BAM 8-22, BAM (8-22), BAM-15
bradykinin  {Sp: Human, Mouse, Rat} 649 BK, kallidin I, kinin 9
brain natriuretic peptide  {Sp: Human} 4890 BNP, BNP(1-32), BNP-32, brain natriuretic peptide 32, Natrecor®
 
C Back to top
C3a  {Sp: Human} 3640 C3a anaphylatoxin, C3a anaphylatoxin polypeptide, complement component C3a
C5a  {Sp: Human} 573 C5a anaphylatoxin, complement component C5a, human complement protein
C3a  {Sp: Mouse} 3641 C3a anaphylatoxin, complement component C3a
C5a  {Sp: Mouse} 3576 C5a anaphylatoxin, complement component C5a
C3a  {Sp: Rat} 3642 C3a anaphylatoxin, C3a anaphylatoxin polypeptide
C5a  {Sp: Rat} 3577 C5a anaphylatoxin, complement component C5a
C3a des Arg  {Sp: Human} 5367
C5a des-Arg  {Sp: Human} 574 C5a des-Arg74
calcitonin  {Sp: Human} 685 CT, LS-173874, thyrocalcitonin
calcitonin  {Sp: Mouse, Rat} 3586 CT
calmodulin  {Sp: Human} 2351 Ca2+/calmodulin, Ca2+/CaM, calcium-calmodulin, CaM
cardiotrophin-1  {Sp: Human} 4906 CTF1, B-cell stimulatory factor 3, BSF3
cardiotrophin-like cytokine factor 1  {Sp: Human} 4895 CLCF1
β-catenin  {Sp: Human} 5371 catenin beta-1
cathepsin G  {Sp: Human} 3570
cathepsin G  {Sp: Mouse} 3571
cathepsin G  {Sp: Rat} 3572
CCK-33  {Sp: Human} 860 CCRIS 3307, cholecystokinin 33
CCK-4  {Sp: Human} 861 cholecystokinin fragment 30-33 amide, tetragastrin
CCK-58  {Sp: Human} 3552
CCK-8  {Sp: Human, Mouse, Rat} 864 CCK-8 (sulphated), cholecystokinin 8, cholecystokinin fragment 26-33 amide (sulphated)
CCK-33  {Sp: Mouse} 3550
CCK-58  {Sp: Mouse} 3553
CCK-33  {Sp: Rat} 3551
CCK-58  {Sp: Rat} 3554
CCL1  {Sp: Human} 812 I309, TCA-3
CCL11  {Sp: Human} 769 eotaxin
CCL13  {Sp: Human} 770 monocyte chemotactic protein-4
CCL14  {Sp: Human} 753 CCL14a, CKβ1, haemofiltrate CC chemokine 1 (HCC-1), HCC-1(1-74)
CCL15  {Sp: Human} 754 Lkn-1 [Leukotactin-1], macrophage inflammatory protein-1δ, MIP-1δ
CCL16  {Sp: Human} 1272
CCL17  {Sp: Human} 797 TARC, thymus- and activation-regulated chemokine
CCL18  {Sp: Human} 4382 macrophage inflammatory protein 4, small-inducible cytokine A18
CCL19  {Sp: Human} 810 β-chemokine exodus-3, ck β-11, ckβ11, MIP-3β
CCL2  {Sp: Human} 771
CCL20  {Sp: Human} 808 LARC, liver and activation-regulated chemokine, macrophage inflammatory protein-3α, MIP-3α
CCL21  {Sp: Human} 811 ckβ9, TCA-4
CCL22  {Sp: Human} 798 dc/β-ck, macrophage-derived chemokine, STCP1
CCL23  {Sp: Human} 755 ckβ8-1, myeloid progenitor inhibitor factor-1
CCL24  {Sp: Human} 775 eotaxin-2
CCL25  {Sp: Human} 817
CCL26  {Sp: Human} 776 MIP-4α, PTEC
CCL27  {Sp: Human} 3646
CCL28  {Sp: Human} 3649
CCL3  {Sp: Human} 756 macrophage inflammatory protein-1α, MIP-1α
CCL4  {Sp: Human} 757 HC21, macrophage inflammatory protein-1β, MIP-1β
CCL5  {Sp: Human} 758 eosinophil chemotactic cytokine [EoCP], regulated upon activation normal T cell expressed and secreted (RANTES)
CCL7  {Sp: Human} 759
CCL8  {Sp: Human} 772 monocyte chemotactic protein-2
CCL1  {Sp: Mouse} 4404
CCL11  {Sp: Mouse} 787 murine eotaxin
CCL12  {Sp: Mouse} 4435
CCL19  {Sp: Mouse} 4417
CCL2  {Sp: Mouse} 4406
CCL20  {Sp: Mouse} 4418
CCL22  {Sp: Mouse} 4420
CCL24  {Sp: Mouse} 4421
CCL25  {Sp: Mouse} 4422
CCL27  {Sp: Mouse} 4462
CCL28  {Sp: Mouse} 4463
CCL3  {Sp: Mouse} 4408
CCL4  {Sp: Mouse} 4410
CCL7  {Sp: Mouse} 4413
CCL8  {Sp: Mouse} 4415
CCL9  {Sp: Mouse} 4434
CCL5  {Sp: Mouse, Rat} 4412
CCL11  {Sp: Rat} 4416
CCL2  {Sp: Rat} 4407
CCL20  {Sp: Rat} 4419
CCL3  {Sp: Rat} 4409
CCL4  {Sp: Rat} 4411
CCL7  {Sp: Rat} 4414
Ccl21a  {Sp: Mouse} 8651 6Ckine-Ser, Exodus-2
Ccl21b  {Sp: Mouse} 8652 6Ckine-Leu, Exodus-2
CD274  {Sp: Human} 7693 PD-L1, B7 homolog 1, B7-H1, PDCD1LG1, programmed cell death 1 ligand 1
CD70  {Sp: Human} 5079 CD27 ligand, Ki-24, TNFSF7
CD30 ligand  {Sp: Human} 5080
CD40 ligand  {Sp: Human} 5077 CD40 ligand, membrane form
α-CGRP  {Sp: Human} 681 α-calcitonin gene-related peptide (αCGRP, human), calcitonin gene-related peptide 1 (CGRP)
β-CGRP  {Sp: Human} 682 β-calcitonin gene-related peptide, βCGRP, calcitonin gene-related peptide 2
β-CGRP  {Sp: Mouse} 3588 β-calcitonin gene-related peptide, βCGRP, calcitonin gene-related peptide 2
α-CGRP  {Sp: Mouse, Rat} 695 αCGRP, rat α-calcitonin gene-related peptide
β-CGRP  {Sp: Rat} 696 βCGRP, rat β-calcitonin gene-related peptide
chemerin  {Sp: Human} 2945 RARRES2, retinoic acid receptor responder protein 2, TIG2
chondroitin sulphate proteoglycan 3  {Sp: Human} 6616 CSPG3, neurocan
choriomammotropin  {Sp: Human} 4893
chorionic gonadotropin beta subunit  {Sp: Human} 4396 CG-beta, choriogonadotropin subunit beta, chorionic gonadotrophin chain beta
chorionic somatomammotropin hormone-like 1  {Sp: Human} 4894 chorionic somatomammotropin-like, lactogen-like
chromogranin A  {Sp: Human} 5165 CgA, pituitary secretory protein I, SP-1
ciliary neurotrophic factor  {Sp: Human} 4897 CNTF
COL1A1  {Sp: Human} 4898 alpha-1 type I collagen, collagen alpha-1(I) chain
COL2A1  {Sp: Human} 4899 alpha-1 type II collagen, collagen alpha-1(II) chain
COL3A1  {Sp: Human} 4900 collagen alpha-1(III) chain
COL4A1  {Sp: Human} 4901 collagen alpha-1(IV) chain
complement C3  {Sp: Human} 9414
complement C5  {Sp: Human} 8712
connective tissue growth factor  {Sp: Human} 8927 CTGF
contactin-1  {Sp: Human} 6617
contactin-3  {Sp: Human} 6609 BIG-1, PANG
contactin-4  {Sp: Human} 6612 BIG-2
contactin-5  {Sp: Human} 6613 hNB-2, NB-2
contactin-6  {Sp: Human} 6614 NB-3, neural adhesion molecule
corticotrophin-releasing hormone  {Sp: Human, Mouse, Rat} 912 CRF
cortistatin-14  {Sp: Mouse, Rat} 2007 CST-14, cortistatin
CRAMP  {Sp: Mouse} 6266
CRCF1/CLCF1 heterodimer  {Sp: Human} 6150
CST-17  {Sp: Human} 2008 cortistatin-17
C-type natriuretic peptide  {Sp: Human} 4896 CNP, CNP-22
CXCL1  {Sp: Human} 819 GROα, melanocyte growth-stimulatory activity, MIP-2
CXCL10  {Sp: Human} 835
CXCL11  {Sp: Human} 836 IP9, ITAC
CXCL12α  {Sp: Human} 4358 CXCL12 α, SDF-1α, stromal cell-derived factor-1α
CXCL12β  {Sp: Human} 845 SDF-1β, stromal cell-derived factor-1 (SDF-1), stromal cell-derived factor-1β
CXCL12δ  {Sp: Human} 8531
CXCL12ε  {Sp: Human} 8532
CXCL12γ  {Sp: Human} 8530
CXCL12φ  {Sp: Human} 8533
CXCL13  {Sp: Human} 3645 BCA-1
CXCL16  {Sp: Human} 855
CXCL17  {Sp: Human} 6479 C-X-C motif chemokine 17, dendritic cell and monocyte chemokine-like protein
CXCL2  {Sp: Human} 827 GROβ, MIP-2α
CXCL3  {Sp: Human} 828 GROγ, MIP-2β
CXCL4  {Sp: Human} 3685 platelet factor 4 (PF4)
CXCL5  {Sp: Human} 829 ENA-78
CXCL6  {Sp: Human} 820
CXCL7  {Sp: Human} 830 PPBP
CXCL8  {Sp: Human} 821 interleukin-8
CXCL9  {Sp: Human} 837 MIG, monokine induced by gamma-interferon
CX3CL1  {Sp: Human} 856 fractalkine, neurotactin
CXCL1  {Sp: Mouse} 4423
CXCL10  {Sp: Mouse} 4430
CXCL11  {Sp: Mouse} 4432
CXCL12  {Sp: Mouse} 4465
CXCL13  {Sp: Mouse} 4466
CXCL16  {Sp: Mouse} 4433
CXCL2  {Sp: Mouse} 4424 macrophage inflammatory protein 2 (MIP-2)
CXCL3  {Sp: Mouse} 4426
CXCL5  {Sp: Mouse} 4428
CXCL9  {Sp: Mouse} 4429
CX3CL1  {Sp: Mouse} 4468
CXCL1  {Sp: Rat} 826 CINC, GROα, macrophage inflammatory protein-2
CXCL10  {Sp: Rat} 4431
CXCL16  {Sp: Rat} 4467
CXCL2  {Sp: Rat} 4425
CXCL3  {Sp: Rat} 4427
CXCL5  {Sp: Rat} 4464
CX3CL1  {Sp: Rat} 4469
cytokine domain of tyrosyl tRNA synthetase  {Sp: Human} 3729
cytokine receptor-like factor 1  {Sp: Human} 4904 CRLF1, NR6
 
D Back to top
delta-like 4 (Drosophila)  {Sp: Human} 8452 DLL4
[des-Arg9]bradykinin  {Sp: Human, Mouse, Rat} 646 [des-Arg9]BK
[des-Arg10]kallidin  {Sp: Human} 644 [Lys,des-Arg9]bradykinin, kallidin1-9, Lys-[des-Arg9]-bradykinin, Lys-[des-Arg9]BK
des-Br-neuropeptide B-23  {Sp: Human} 1499 des-Br-NPB-23
des-Br-neuropeptide B-29  {Sp: Human} 1500 des-Br-NPB-29
[des-Gln14]ghrelin  {Sp: Human} 3600 des-Gln14-ghrelin
[des-Gln14]ghrelin  {Sp: Mouse, Rat} 3601
[des-octanoyl]ghrelin  {Sp: Human} 1098 [des-octanoyl] ghrelin, des-octanoyl ghrelin
[des-octanoyl]ghrelin  {Sp: Mouse, Rat} 3599 des-octanoyl ghrelin
desulfated gastrin-14  {Sp: Human} 3558 minigastrin
desulfated gastrin-17  {Sp: Human} 8408 little gastrin I
desulfated gastrin-34  {Sp: Human} 8409
desulfated gastrin-71  {Sp: Human} 8410
Dickkopf 1  {Sp: Human} 3701 Dickkopf-related protein 1, DKK 1
dynorphin A  {Sp: Human, Mouse, Rat} 1620 dynA, dynorphin 1-17, dynorphin A (1-17)
dynorphin A-(1-13)  {Sp: Human, Mouse, Rat} 1619 dynorphin 1-13, dynorphin A (1-13)
dynorphin A-(1-8)  {Sp: Human, Mouse, Rat} 1621 dynorphin A (1-8)
dynorphin B  {Sp: Human, Mouse, Rat} 1622 rimorphin
 
E Back to top
ectodysplasin A1  {Sp: Human} 6144 ectodysplasin-A isoform 1, ectodysplasin-A, membrane form, membrane isoform of ectodysplasin-A
ectodysplasin A2  {Sp: Human} 6143 ectodysplasin-A, secreted form, secreted form of ectodysplasin-A
EGF  {Sp: Human} 4916 urogastrone
Elabela/Toddler-11  {Sp: Human} 8526 ELA-11
Elabela/Toddler-21  {Sp: Human} 8525 ELA-21
Elabela/Toddler-32  {Sp: Human} 8524 ELA-32
endomorphin-1  {Sp: Human} 1623
endomorphin-2  {Sp: Human} 3668
β-endorphin  {Sp: Human} 1643 β-end
β-endorphin  {Sp: Mouse} 3722 β-end
β-endorphin  {Sp: Rat} 3723 β-end
endothelin-2  {Sp: Human} 990 ET-2
endothelin-1  {Sp: Human, Mouse, Rat} 989 ET-1
endothelin-3  {Sp: Human, Mouse, Rat} 1004 ET-3
endothelin-2  {Sp: Mouse, Rat} 3546 ET-2
ephrin-A1  {Sp: Human} 4908 EFNA1, EPH-related receptor tyrosine kinase ligand 1, immediate early response protein B61, TNF alpha-induced protein 4, tumor necrosis factor alpha-induced protein 4 (TNFAIP4)
ephrin-A2  {Sp: Human} 4909 EFNA2, EPH-related receptor tyrosine kinase ligand 6, HEK7 ligand, HEK7-L
ephrin-A3  {Sp: Human} 4910 EFNA3, EFL-2, EHK1 ligand, EPH-related receptor tyrosine kinase ligand 3
ephrin-A4  {Sp: Human} 4911 EFNA4, EPH-related receptor tyrosine kinase ligand 4, LERK-4
ephrin-A5  {Sp: Human} 4912 EFNA5, AL-1, EPH-related receptor tyrosine kinase ligand 7, LERK-7
ephrin-B1  {Sp: Human} 4913 EFNB1, EFL-3, ELK ligand, EPH-related receptor tyrosine kinase ligand 2, LERK-2
ephrin-B2  {Sp: Human} 4914 EFNB2, LERK-5
ephrin-B3  {Sp: Human} 4915 EFNB3, EPH-related receptor transmembrane ligand ELK-L3, EPH-related receptor tyrosine kinase ligand 8
epigen  {Sp: Human} 4917 EPG, epithelial mitogen
epiregulin  {Sp: Human} 4918
erythropoietin  {Sp: Human} 4921 Epogen®, Procrit®
 
F Back to top
Fas ligand  {Sp: Human} 5078 apoptosis antigen ligand, CD95L
FGF-1  {Sp: Human} 4923 acidic fibroblast growth factor, beta-endothelial cell growth factor, heparin-binding growth factor 1 (HBGF-1)
FGF-2  {Sp: Human} 4924 basic fibroblast growth factor (bFGF), fibroblast growth factor 2 (FGF-2), heparin-binding growth factor 2 (HBGF-2)
FGF-23  {Sp: Human} 9291 fibroblast growth factor 23
FGF-4  {Sp: Human} 4925 heparin secretory-transforming protein 1 (HST-1), heparin-binding growth factor 4 (HBGF-4), transforming protein KS3
FGF-5  {Sp: Human} 4926 HBGF-5, heparin-binding growth factor 5, Smag-82
FGF-6  {Sp: Human} 4927 heparin secretory-transforming protein 2 (HST-2), heparin-binding growth factor 6 (HBGF-6), HSTF-2
FGF-7  {Sp: Human} 4928 HBGF-7, heparin-binding growth factor 7
FGF-8  {Sp: Human} 4929 androgen-induced growth factor (AIGF), heparin-binding growth factor 8 (HBGF-8)
FGF-9  {Sp: Human} 4930 glia-activating factor (GAF), heparin-binding growth factor 9 (HBGF-9)
fibrinogen  {Sp: Human} 6749
fibrinogen alpha chain  {Sp: Human} 6750
fibrinogen beta chain  {Sp: Human} 6751
fibrinogen gamma chain  {Sp: Human} 6752
fibronectin  {Sp: Human} 6754
F2L  {Sp: Human} 3935