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SLC20 family of sodium-dependent phosphate transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The SLC20 family is looked upon not only as ion transporters, but also as retroviral receptors. As ion transporters, they are sometimes referred to as Type III sodium-phosphate co-transporters, alongside Type I (SLC17 family) and Type II (SLC34 family). PiTs are cell-surface transporters, composed of ten TM domains with extracellular C- and N-termini. PiT1 is a focus for dietary phosphate and vitamin D regulation of parathyroid hormone secretion from the parathyroid gland. PiT2 appears to be involved in intestinal absorption of dietary phosphate.

Transporters

1018
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PiT1 (Sodium-dependent phosphate transporter 1 / SLC20A1) C Show summary »

PiT2 (Sodium-dependent phosphate transporter 2 / SLC20A2) C Show summary »

Target Id 1018
Nomenclature Sodium-dependent phosphate transporter 2
Systematic nomenclature SLC20A2
Common abbreviation PiT2
Previous and unofficial names Gibbon ape leukemia virus receptor 2 | GLVR2 | Ab1-188 | phosphate transporter 2 | Ram1 | receptor for amphitropic viruses 1 | solute carrier family 20 member 2 | solute carrier family 20 (phosphate transporter), member 2 | solute carrier family 20
Genes SLC20A2 (Hs), Slc20a2 (Mm), Slc20a2 (Rn)
Ensembl ID ENSG00000168575 (Hs), ENSMUSG00000037656 (Mm), ENSRNOG00000019490 (Rn)
UniProtKB AC Q08357 (Hs), Q80UP8 (Mm), Q63488 (Rn)
Bioparadigms SLC Tables SLC20A2 (Hs)
RESOLUTE SLC20A2 (Hs)
Substrates
phosphate [1]
Stoichiometry >1 Na+ : 1 HPO42- (in)

Further reading

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References

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How to cite this family page

Database page citation:

SLC20 family of sodium-dependent phosphate transporters. Accessed on 25/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=195.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.