SLC23 family of ascorbic acid transporters | Transporters

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SLC superfamily of solute carriers
SLC23 family of ascorbic acid transporters

SLC23 family of ascorbic acid transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Predicted to be 12 TM segment proteins, members of this family transport the reduced form of ascorbic acid (while the oxidized form may be handled by members of the SLC2 family (GLUT1/SLC2A1, GLUT3/SLC2A3 and GLUT4/SLC2A4). Phloretin is considered a non-selective inhibitor of these transporters, with an affinity in the micromolar range [1].

Transporters

1041

SVCT1 (Sodium-dependent vitamin C transporter 1 / SLC23A1) C Show summary »« Hide summary

Target Id

1041

Nomenclature

Sodium-dependent vitamin C transporter 1

Systematic nomenclature

SLC23A1

Common abbreviation

SVCT1

Previous and unofficial names

Genes

SLC23A1 (Hs), Slc23a1 (Mm), Slc23a1 (Rn)

Ensembl ID

ENSG00000170482 (Hs), ENSMUSG00000024354 (Mm), ENSRNOG00000061695 (Rn)

UniProtKB AC

Q9UHI7 (Hs), Q9Z2J0 (Mm), Q9WTW7 (Rn)

Bioparadigms SLC Tables

SLC23A1 (Hs)

RESOLUTE

SLC23A1 (Hs)

Endogenous substrates

L-ascorbic acid > D-ascorbic acid > dehydroascorbic acid [3]

Inhibitors

phloretin pK_i 4.2 [3]

Labelled ligands

[¹⁴C]ascorbic acid (Binding) [2]

Stoichiometry

2 Na⁺: 1 ascorbic acid (in) [3]

SVCT2 (Sodium-dependent vitamin C transporter 2 / SLC23A2) C Show summary »« Hide summary

Target Id

1042

Nomenclature

Sodium-dependent vitamin C transporter 2

Systematic nomenclature

SLC23A2

Common abbreviation

SVCT2

Previous and unofficial names

Genes

SLC23A2 (Hs), Slc23a2 (Mm), Slc23a2 (Rn)

Ensembl ID

ENSG00000089057 (Hs), ENSMUSG00000027340 (Mm), ENSRNOG00000021262 (Rn)

UniProtKB AC

Q9UGH3 (Hs), Q9EPR4 (Mm), Q9WTW8 (Rn)

Bioparadigms SLC Tables

SLC23A2 (Hs)

RESOLUTE

SLC23A2 (Hs)

Endogenous substrates

L-ascorbic acid > D-ascorbic acid > dehydroascorbic acid [3]

Labelled ligands

[¹⁴C]ascorbic acid

Stoichiometry

2 Na⁺: 1 ascorbic acid (in) [3]

SVCT3 (Sodium-dependent vitamin C transporter 3 / SLC23A3) C Show summary »« Hide summary

Target Id	1043
Nomenclature	Sodium-dependent vitamin C transporter 3
Systematic nomenclature	SLC23A3
Common abbreviation	SVCT3
Previous and unofficial names	Yolk sac permease-like molecule 1 \| SVCT3 \| Yspl1 \| solute carrier family 23 (nucleobase transporters), member 3 \| solute carrier family 23, member 3 \| solute carrier family 23 \| solute carrier family 23 (nucleobase transporters)
Genes	SLC23A3 (Hs), Slc23a3 (Mm), Slc23a3 (Rn)
Ensembl ID	ENSG00000213901 (Hs), ENSMUSG00000026205 (Mm), ENSRNOG00000018266 (Rn)
UniProtKB AC	Q6PIS1 (Hs), Q60850 (Mm)
Bioparadigms SLC Tables	SLC23A3 (Hs)
RESOLUTE	SLC23A3 (Hs)
Comment	SLC23A3 does not transport ascorbic acid and remains an orphan transporter.

SNBT1 (Sodium-dependent nucleobase transporter / SLC23A4) C Show summary »« Hide summary

Target Id

1044

Nomenclature

Sodium-dependent nucleobase transporter

Systematic nomenclature

SLC23A4

Common abbreviation

SNBT1

Previous and unofficial names

solute carrier family 23 (nucleobase transporters), member 4 | solute carrier family 23 (nucleobase transporters), member 4, pseudogene | similar to Solute carrier family 23, member 2 (Sodium-dependent vitamin C transporter 2) | similar to Solute carrier family 23 | 2010107G12Rik | RIKEN cDNA 2010107G12 gene | RGD1565367

Genes

SLC23A4P (Hs), Slc23a4 (Mm), Slc23a4 (Rn)

Ensembl ID

ENSG00000276067 (Hs), ENSMUSG00000029847 (Mm), ENSRNOG00000026919 (Rn)

Endogenous substrates

uracil > thymine > guanine, hypoxanthine > xanthine, uridine [4]

Substrates

5-fluorouracil [4]

Stoichiometry

1 Na⁺ : 1 uracil (in) [4]

Comment

SLC23A4/SNBT1 is found in rodents and non-human primates, but the sequence is truncated in the human genome and named as a pseudogene, SLC23A4P

References

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1. Alexander SPH, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL et al.. (2019) THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Transporters. Br J Pharmacol, 176 Suppl 1: S397-S493. [PMID:31710713]

2. MacDonald L, Thumser AE, Sharp P. (2002) Decreased expression of the vitamin C transporter SVCT1 by ascorbic acid in a human intestinal epithelial cell line. Br J Nutr, 87 (2): 97-100. [PMID:11895172]

3. Tsukaguchi H, Tokui T, Mackenzie B, Berger UV, Chen XZ, Wang Y, Brubaker RF, Hediger MA. (1999) A family of mammalian Na+-dependent L-ascorbic acid transporters. Nature, 399 (6731): 70-5. [PMID:10331392]

4. Yamamoto S, Inoue K, Murata T, Kamigaso S, Yasujima T, Maeda JY, Yoshida Y, Ohta KY, Yuasa H. (2010) Identification and functional characterization of the first nucleobase transporter in mammals: implication in the species difference in the intestinal absorption mechanism of nucleobases and their analogs between higher primates and other mammals. J Biol Chem, 285 (9): 6522-31. [PMID:20042597]

NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.

SLC23 family of ascorbic acid transporters C

Overview

Transporters

Further reading

References

NC-IUPHAR subcommittee and family contributors

How to cite this family page