SLC25 mitochondrial vitamin and co-factor carriers subfamily | Transporters

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SLC superfamily of solute carriers
SLC25 family of mitochondrial transporters
SLC25 mitochondrial vitamin and co-factor carriers subfamily

SLC25 mitochondrial vitamin and co-factor carriers subfamily C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Transporters

1073

TPC (Thiamine pyrophosphate carrier / SLC25A19) C Show summary »« Hide summary

Target Id

1073

Nomenclature

Thiamine pyrophosphate carrier

Systematic nomenclature

SLC25A19

Common abbreviation

TPC

Previous and unofficial names

Genes

SLC25A19 (Hs), Slc25a19 (Mm), Slc25a19 (Rn)

Ensembl ID

ENSG00000125454 (Hs), ENSMUSG00000020744 (Mm), ENSRNOG00000003918 (Rn)

UniProtKB AC

Q9HC21 (Hs), Q9DAM5 (Mm)

Bioparadigms SLC Tables

SLC25A19 (Hs)

RESOLUTE

SLC25A19 (Hs)

Substrates

Deoxynucleotide Diphosphates (dNDPs)

Deoxynucleotide Triphosphates (dNTPs)

Dideoxynucleotide Triphosphates (ddNTPs)

Nucleotide Diphosphates (NDPs)

Stoichiometry

thiamine pyrophosphate (in) : thiamine monophosphate (out)

Comment

Previously this transporter was incorrectly identified as the deoxynucleotide carrier 1 (DNC). Substrates are dATP, thiamin pyrophosphate and thiamine monophosphate [5].

PLPC (Pyridoxal 5′-phosphate carrier / SLC25A38) C Show summary »« Hide summary

Target Id

1089

Nomenclature

Pyridoxal 5′-phosphate carrier

Systematic nomenclature

SLC25A38

Common abbreviation

PLPC

Previous and unofficial names

solute carrier family 25 member 38 | solute carrier family 25

Genes

SLC25A38 (Hs), Slc25a38 (Mm), Slc25a38 (Rn)

Ensembl ID

ENSG00000144659 (Hs), ENSMUSG00000032519 (Mm), ENSRNOG00000018552 (Rn)

UniProtKB AC

Q96DW6 (Hs), Q91XD8 (Mm), Q499U1 (Rn)

Bioparadigms SLC Tables

SLC25A38 (Hs)

RESOLUTE

SLC25A38 (Hs)

Substrates

Pyridoxal 5′-phosphate [7]

Stoichiometry

Pyridoxal 5′-phosphate (in)

Comment

This transporter was previously incorrectly identified as the glycine transporter.

SAMC (S-Adenosylmethionine carrier / SLC25A26) C Show summary »« Hide summary

Target Id

1074

Nomenclature

S-Adenosylmethionine carrier

Systematic nomenclature

SLC25A26

Common abbreviation

SAMC

Previous and unofficial names

solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26 | SAMC | solute carrier family 25 (S-adenosylmethionine carrier), member 26 | solute carrier family 25 (mitochondrial carrier

Genes

SLC25A26 (Hs), Slc25a26 (Mm), Slc25a26 (Rn)

Ensembl ID

ENSG00000144741 (Hs), ENSMUSG00000045100 (Mm), ENSRNOG00000012831 (Rn)

UniProtKB AC

Q70HW3 (Hs), Q5U680 (Mm)

Bioparadigms SLC Tables

SLC25A26 (Hs)

RESOLUTE

SLC25A26 (Hs)

Substrates

S-adenosyl methionine

Stoichiometry

S-adenosyl-L-homocysteine (out) : S-adenosyl-L-methionine (in)
S-adenosyl-L-homocysteine (in) : S-adenosyl-L-methionine (out)

Comment

Substrates are S-adenosyl-L-homocysteine and S-adenosyl-L-methionine [1].

FLXC (Folate carrier / SLC25A32) C Show summary »« Hide summary

Target Id	1083
Nomenclature	Folate carrier
Systematic nomenclature	SLC25A32
Common abbreviation	FLXC
Previous and unofficial names	MFTC \| mitochondrial folate transporter/carrier \| solute carrier family 25 (mitochondrial folate carrier) , member 32 \| solute carrier family 25 (mitochondrial folate carrier), member 32 \| solute carrier family 25
Genes	SLC25A32 (Hs), Slc25a32 (Mm), Slc25a32 (Rn)
Ensembl ID	ENSG00000164933 (Hs), ENSMUSG00000022299 (Mm), ENSRNOG00000004403 (Rn)
UniProtKB AC	Q9H2D1 (Hs), Q8BMG8 (Mm)
Bioparadigms SLC Tables	SLC25A32 (Hs)
RESOLUTE	SLC25A32 (Hs)
Stoichiometry	folate (in) FMN/FAD (in)
Comment	Substrates are folate and/or FMN/FAD [10-11]. The precise transport mechanism via SLC25A32 remains unresolved.

NADT1 (Mitochondrial nicotinamide adenine dinucleotide transporter 1 / SLC25A51) C Show summary »« Hide summary

Target Id	2560
Nomenclature	Mitochondrial nicotinamide adenine dinucleotide transporter 1
Systematic nomenclature	SLC25A51
Common abbreviation	NADT1
Previous and unofficial names	MCART1 \| mitochondrial carrier triple repeat 1 \| solute carrier family 25, member 51 \| solute carrier family 25
Genes	SLC25A51 (Hs), Slc25a51 (Mm)
Ensembl ID	ENSG00000122696 (Hs), ENSMUSG00000045973 (Mm)
UniProtKB AC	Q9H1U9 (Hs), Q5HZI9 (Mm)
Bioparadigms SLC Tables	SLC25A51 (Hs)
RESOLUTE	SLC25A51 (Hs)
Stoichiometry	NAD⁺ (in)
Comment	Substrate is NAD⁺ [3-4,6]. Related to SLC25A52 (NADT2).

NADT2 (Mitochondrial nicotinamide adenine dinucleotide transporter 2 / SLC25A52) C Show summary »« Hide summary

Target Id	2561
Nomenclature	Mitochondrial nicotinamide adenine dinucleotide transporter 2
Systematic nomenclature	SLC25A52
Common abbreviation	NADT2
Previous and unofficial names	MCART2 \| mitochondrial carrier triple repeat 2 \| solute carrier family 25, member 52 \| solute carrier family 25
Genes	SLC25A52 (Hs), Slc25a52 (Rn)
Ensembl ID	ENSG00000141437 (Hs), ENSRNOG00000033251 (Rn)
UniProtKB AC	Q3SY17 (Hs)
Bioparadigms SLC Tables	SLC25A52 (Hs)
RESOLUTE	SLC25A52 (Hs)
Stoichiometry	NAD⁺ (in)
Comment	Substrate is NAD⁺ [3-4,6]. Related to SLC25A51 (NADT1).

GSHC1 (Mitochondrial glutathione transporter 1 / SLC25A39) C Show summary »« Hide summary

Target Id

1090

Nomenclature

Mitochondrial glutathione transporter 1

Systematic nomenclature

SLC25A39

Common abbreviation

GSHC1

Previous and unofficial names

CGI-69 | solute carrier family 25 | solute carrier family 25 member 39

Genes

SLC25A39 (Hs), Slc25a39 (Mm), Slc25a39 (Rn)

Ensembl ID

ENSG00000013306 (Hs), ENSMUSG00000018677 (Mm), ENSRNOG00000020994 (Rn)

UniProtKB AC

Q9BZJ4 (Hs), Q9D8K8 (Mm), Q4V8K4 (Rn)

Bioparadigms SLC Tables

SLC25A39 (Hs)

RESOLUTE

SLC25A39 (Hs)

Substrates

glutathione [8-9,12]

Stoichiometry

glutathione (in) : glutathione (out)

Comment

Related to SLC25A40 (GSHC2).

Mitochondrial glutathione transporter 2 / SLC25A40 C Show summary »« Hide summary

Target Id

1091

Nomenclature

Mitochondrial glutathione transporter 2

Systematic nomenclature

SLC25A40

Previous and unofficial names

MCFP | solute carrier family 25 | solute carrier family 25 member 40

Genes

SLC25A40 (Hs), Slc25a40 (Mm), Slc25a40 (Rn)

Ensembl ID

ENSG00000075303 (Hs), ENSMUSG00000054099 (Mm), ENSRNOG00000022837 (Rn)

UniProtKB AC

Q8TBP6 (Hs), Q8BGP6 (Mm), Q498U3 (Rn)

Bioparadigms SLC Tables

SLC25A40 (Hs)

RESOLUTE

SLC25A40 (Hs)

Substrates

glutathione [8-9,12]

Stoichiometry

glutathione (in) : glutathione (out)

Comment

Related to SLC25A39 (GSHC1).

CoAT (Mitochondrial Coenzyme A transporter / SLC25A42) C Show summary »« Hide summary

Target Id

1075

Nomenclature

Mitochondrial Coenzyme A transporter

Systematic nomenclature

SLC25A42

Common abbreviation

CoAT

Previous and unofficial names

solute carrier family 25 member 42 | solute carrier family 25

Genes

SLC25A42 (Hs), Slc25a42 (Mm), Slc25a42 (Rn)

Ensembl ID

ENSG00000181035 (Hs), ENSMUSG00000002346 (Mm), ENSRNOG00000020345 (Rn)

UniProtKB AC

Q86VD7 (Hs), Q8R0Y8 (Mm), P0C546 (Rn)

Bioparadigms SLC Tables

SLC25A42 (Hs)

RESOLUTE

SLC25A42 (Hs)

Substrates

ADP

Stoichiometry

Coenzyme A (in)

Comment

Substrate is Coenzyme A (CoA) [2].

References

Show »« Hide

1. Agrimi G, Di Noia MA, Marobbio CM, Fiermonte G, Lasorsa FM, Palmieri F. (2004) Identification of the human mitochondrial S-adenosylmethionine transporter: bacterial expression, reconstitution, functional characterization and tissue distribution. Biochem J, 379 (Pt 1): 183-90. [PMID:14674884]

2. Fiermonte G, Paradies E, Todisco S, Marobbio CM, Palmieri F. (2009) A novel member of solute carrier family 25 (SLC25A42) is a transporter of coenzyme A and adenosine 3',5'-diphosphate in human mitochondria. J Biol Chem, 284 (27): 18152-9. [PMID:19429682]

3. Girardi E, Agrimi G, Goldmann U, Fiume G, Lindinger S, Sedlyarov V, Srndic I, Gürtl B, Agerer B, Kartnig F et al.. (2020) Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import. Nat Commun, 11 (1): 6145. [PMID:33262325]

4. Kory N, Uit de Bos J, van der Rijt S, Jankovic N, Güra M, Arp N, Pena IA, Prakash G, Chan SH, Kunchok T et al.. (2020) MCART1/SLC25A51 is required for mitochondrial NAD transport. Sci Adv, 6 (43). [PMID:33087354]

5. Lindhurst MJ, Fiermonte G, Song S, Struys E, De Leonardis F, Schwartzberg PL, Chen A, Castegna A, Verhoeven N, Mathews CK et al.. (2006) Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia. Proc Natl Acad Sci U S A, 103 (43): 15927-32. [PMID:17035501]

6. Luongo TS, Eller JM, Lu MJ, Niere M, Raith F, Perry C, Bornstein MR, Oliphint P, Wang L, McReynolds MR et al.. (2020) SLC25A51 is a mammalian mitochondrial NAD⁺ transporter. Nature, 588 (7836): 174-179. [PMID:32906142]

7. Pena IA, Shi JS, Chang SM, Yang J, Block S, Adelmann CH, Keys HR, Ge P, Bathla S, Witham IH et al.. (2025) SLC25A38 is required for mitochondrial pyridoxal 5'-phosphate (PLP) accumulation. Nat Commun, 16 (1): 978. [PMID:39856062]

8. Shi X, DeCiucis M, Grabinska KA, Kanyo J, Liu A, Lam TT, Shen H. (2024) Dual regulation of SLC25A39 by AFG3L2 and iron controls mitochondrial glutathione homeostasis. Mol Cell, 84 (4): 802-810.e6. [PMID:38157846]

9. Shi X, Reinstadler B, Shah H, To TL, Byrne K, Summer L, Calvo SE, Goldberger O, Doench JG, Mootha VK et al.. (2022) Combinatorial GxGxE CRISPR screen identifies SLC25A39 in mitochondrial glutathione transport linking iron homeostasis to OXPHOS. Nat Commun, 13 (1): 2483. [PMID:35513392]

10. Spaan AN, Ijlst L, van Roermund CW, Wijburg FA, Wanders RJ, Waterham HR. (2005) Identification of the human mitochondrial FAD transporter and its potential role in multiple acyl-CoA dehydrogenase deficiency. Mol Genet Metab, 86 (4): 441-7. [PMID:16165386]

11. Titus SA, Moran RG. (2000) Retrovirally mediated complementation of the glyB phenotype. Cloning of a human gene encoding the carrier for entry of folates into mitochondria. J Biol Chem, 275 (47): 36811-7. [PMID:10978331]

12. Wang Y, Yen FS, Zhu XG, Timson RC, Weber R, Xing C, Liu Y, Allwein B, Luo H, Yeh HW et al.. (2021) SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells. Nature, 599 (7883): 136-140. [PMID:34707288]

How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.