Anion channels | Transporters | IUPHAR/BPS Guide to PHARMACOLOGY

Anion channels C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Transporters

1103

SLC26A7 C Show summary »« Hide summary

Target Id	1102
Systematic nomenclature	SLC26A7
Previous and unofficial names	SUT2 \| anion exchange transporter \| solute carrier family 26, member 7 \| solute carrier family 26 (anion exchanger), member 7 \| solute carrier family 26
Genes	SLC26A7 (Hs), Slc26a7 (Mm), Slc26a7 (Rn)
Ensembl ID	ENSG00000147606 (Hs), ENSMUSG00000040569 (Mm), ENSRNOG00000006096 (Rn)
UniProtKB AC	Q8TE54 (Hs), Q8R2Z3 (Mm)
Bioparadigms SLC Tables	SLC26A7 (Hs)
RESOLUTE	SLC26A7 (Hs)
Substrates	NO₃^- >> Cl^- = Br^- = I^- > SO₄^2- = L-glutamic acid
Functional characteristics	Voltage- and time-independent current, linear I-V relationship [3]

SLC26A9 C Show summary »« Hide summary

Target Id	1103
Systematic nomenclature	SLC26A9
Previous and unofficial names	anion transporter/exchanger-9 \| solute carrier family 26 member 9 \| solute carrier family 26 (anion exchanger), member 9 \| solute carrier family 26
Genes	SLC26A9 (Hs), Slc26a9 (Mm), Slc26a9 (Rn)
Ensembl ID	ENSG00000174502 (Hs), ENSMUSG00000042268 (Mm), ENSRNOG00000029514 (Rn)
UniProtKB AC	Q7LBE3 (Hs), Q8BU91 (Mm)
Bioparadigms SLC Tables	SLC26A9 (Hs)
RESOLUTE	SLC26A9 (Hs)
Substrates	I^- > Br^- > NO₃^- > Cl^- > L-glutamic acid
Functional characteristics	Voltage- and time-independent current, linear I-V relationship [2]
Comment	SLC26A9 has been suggested to operate in two additional modes as a Cl^--HCO₃^- exchanger and as a Na⁺-anion cotransporter [1].

References

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1. Chang MH, Plata C, Zandi-Nejad K, Sindić A, Sussman CR, Mercado A, Broumand V, Raghuram V, Mount DB, Romero MF. (2009) Slc26a9--anion exchanger, channel and Na+ transporter. J Membr Biol, 228 (3): 125-40. [PMID:19365592]

2. Dorwart MR, Shcheynikov N, Wang Y, Stippec S, Muallem S. (2007) SLC26A9 is a Cl(-) channel regulated by the WNK kinases. J Physiol (Lond.), 584 (Pt 1): 333-45. [PMID:17673510]

3. Kim KH, Shcheynikov N, Wang Y, Muallem S. (2005) SLC26A7 is a Cl- channel regulated by intracellular pH. J Biol Chem, 280 (8): 6463-70. [PMID:15591059]

How to cite this family page

Database page citation:

Anion channels. Accessed on 25/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=212.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.