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SLC39 family of metal ion transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Along with the SLC30 family, SLC39 family members regulate zinc movement in cells. SLC39 metal ion transporters accumulate zinc into the cytosol. Membrane topology modelling suggests the presence of eight TM regions with both termini extracellular or in the lumen of intracellular organelles. The mechanism for zinc transport for many members is unknown but appears to involve co-transport of bicarbonate ions [2,4].

Transporters

1187
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ZIP1 (Zinc transporter 1 / SLC39A1) Show summary »

ZIP2 (Zinc transporter 2 / SLC39A2) Show summary »

ZIP3 (Zinc transporter 3 / SLC39A3) Show summary »

ZIP4 (Zinc transporter 4 / SLC39A4) Show summary »

ZIP5 (Zinc transporter 5 / SLC39A5) Show summary »

ZIP6 (Zinc transporter 6 / SLC39A6) Show summary »

ZIP7 (Zinc transporter 7 / SLC39A7) Show summary »

ZIP8 (Zinc transporter 8 / SLC39A8) C Show summary »


Target Id 1187
Nomenclature Zinc transporter 8
Systematic nomenclature SLC39A8
Common abbreviation ZIP8
Previous and unofficial names BIGM103 | solute carrier family 39 (metal ion transporter), member 8 | zrt- and Irt-like protein 8 | solute carrier family 39 (zinc transporter), member 8 | solute carrier family 39 (metal ion transporter)
Genes SLC39A8 (Hs), Slc39a8 (Mm), Slc39a8 (Rn)
Ensembl ID ENSG00000138821 (Hs), ENSMUSG00000053897 (Mm), ENSRNOG00000012508 (Rn)
UniProtKB AC Q9C0K1 (Hs), Q91W10 (Mm), Q5FVQ0 (Rn)
Bioparadigms SLC Tables SLC39A8 (Hs)
RESOLUTE SLC39A8 (Hs)
Substrates
Cd2+ [1,4]
Stoichiometry 1 Zn2+ (in) : 2 HCO3- (in) [4]
Comment Essential for manganese (Mn) homeostasis; reclaims Mn from bile and is important for Mn uptake in the brain [3].

ZIP9 (Zinc transporter 9 / SLC39A9) Show summary »

ZIP10 (Zinc transporter 10 / SLC39A10) Show summary »

ZIP11 (Zinc transporter 11 / SLC39A11) Show summary »

ZIP12 (Zinc transporter 12 / SLC39A12) Show summary »

ZIP13 (Zinc transporter 13 / SLC39A13) Show summary »

ZIP14 (Zinc transporter 14 / SLC39A14) C Show summary »

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Further reading

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.