SLC39 family of metal ion transporters | Transporters

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SLC superfamily of solute carriers
SLC39 family of metal ion transporters

SLC39 family of metal ion transporters C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Along with the SLC30 family, SLC39 family members regulate zinc movement in cells. SLC39 metal ion transporters accumulate zinc into the cytosol. Membrane topology modelling suggests the presence of eight TM regions with both termini extracellular or in the lumen of intracellular organelles. The mechanism for zinc transport for many members is unknown but appears to involve co-transport of bicarbonate ions [2,4].

Transporters

1193

ZIP1 (Zinc transporter 1 / SLC39A1) Show summary »« Hide summary

Target Id	1180
Nomenclature	Zinc transporter 1
Systematic nomenclature	SLC39A1
Common abbreviation	ZIP1
Previous and unofficial names	Zinc/iron-regulated transporter-like; ZIRTL \| ZRT- and IRT-like protein 1 \| solute carrier family 39 (zinc transporter), member 1 \| solute carrier family 39 (zinc transporter)
Genes	SLC39A1 (Hs), Slc39a1 (Mm), Slc39a1 (Rn)
Ensembl ID	ENSG00000143570 (Hs), ENSMUSG00000052310 (Mm), ENSRNOG00000059463 (Rn)
UniProtKB AC	Q9NY26 (Hs), Q9QZ03 (Mm)
Bioparadigms SLC Tables	SLC39A1 (Hs)
RESOLUTE	SLC39A1 (Hs)

ZIP2 (Zinc transporter 2 / SLC39A2) Show summary »« Hide summary

Target Id	1181
Nomenclature	Zinc transporter 2
Systematic nomenclature	SLC39A2
Common abbreviation	ZIP2
Previous and unofficial names	ZRT- and IRT-like protein 2 \| solute carrier family 39 (zinc transporter), member 2 \| solute carrier family 39 (zinc transporter)
Genes	SLC39A2 (Hs), Slc39a2 (Mm), Slc39a2 (Rn)
Ensembl ID	ENSG00000165794 (Hs), ENSMUSG00000072572 (Mm), ENSRNOG00000010375 (Rn)
UniProtKB AC	Q9NP94 (Hs)
Bioparadigms SLC Tables	SLC39A2 (Hs)
RESOLUTE	SLC39A2 (Hs)

ZIP3 (Zinc transporter 3 / SLC39A3) Show summary »« Hide summary

Target Id	1182
Nomenclature	Zinc transporter 3
Systematic nomenclature	SLC39A3
Common abbreviation	ZIP3
Previous and unofficial names	ZRT- and IRT-like protein 3 \| solute carrier family 39 member 3 \| solute carrier family 39 (zinc transporter), member 3 \| solute carrier family 39 (zinc transporter)
Genes	SLC39A3 (Hs), Slc39a3 (Mm), Slc39a3 (Rn)
Ensembl ID	ENSG00000141873 (Hs), ENSMUSG00000046822 (Mm), ENSRNOG00000045524 (Rn)
UniProtKB AC	Q9BRY0 (Hs), Q99K24 (Mm), Q5U1X7 (Rn)
Bioparadigms SLC Tables	SLC39A3 (Hs)
RESOLUTE	SLC39A3 (Hs)

ZIP4 (Zinc transporter 4 / SLC39A4) Show summary »« Hide summary

Target Id	1183
Nomenclature	Zinc transporter 4
Systematic nomenclature	SLC39A4
Common abbreviation	ZIP4
Previous and unofficial names	ZRT- and IRT-like protein 4 \| solute carrier family 39 member 4 \| solute carrier family 39 (zinc transporter), member 4 \| solute carrier family 39 (zinc transporter)
Genes	SLC39A4 (Hs), Slc39a4 (Mm), Slc39a4 (Rn)
Ensembl ID	ENSG00000147804 (Hs), ENSMUSG00000063354 (Mm), ENSRNOG00000014314 (Rn)
UniProtKB AC	Q6P5W5 (Hs), Q78IQ7 (Mm), A0JPN2 (Rn)
Bioparadigms SLC Tables	SLC39A4 (Hs)
RESOLUTE	SLC39A4 (Hs)

ZIP5 (Zinc transporter 5 / SLC39A5) Show summary »« Hide summary

Target Id	1184
Nomenclature	Zinc transporter 5
Systematic nomenclature	SLC39A5
Common abbreviation	ZIP5
Previous and unofficial names	solute carrier family 39 (metal ion transporter), member 5 \| solute carrier family 39 (zinc transporter), member 5 \| solute carrier family 39 (metal ion transporter)
Genes	SLC39A5 (Hs), Slc39a5 (Mm), Slc39a5 (Rn)
Ensembl ID	ENSG00000139540 (Hs), ENSMUSG00000039878 (Mm), ENSRNOG00000033361 (Rn)
UniProtKB AC	Q6ZMH5 (Hs), Q9D856 (Mm)
Bioparadigms SLC Tables	SLC39A5 (Hs)
RESOLUTE	SLC39A5 (Hs)

ZIP6 (Zinc transporter 6 / SLC39A6) Show summary »« Hide summary

Target Id	1185
Nomenclature	Zinc transporter 6
Systematic nomenclature	SLC39A6
Common abbreviation	ZIP6
Previous and unofficial names	solute carrier family 39 (metal ion transporter) \| Ermelin \| LIV1 \| LIV-1 \| solute carrier family 39 (metal ion transporter), member 6 \| solute carrier family 39 (zinc transporter), member 6 \| zrt- and Irt-like protein 6
Genes	SLC39A6 (Hs), Slc39a6 (Mm), Slc39a6 (Rn)
Ensembl ID	ENSG00000141424 (Hs), ENSMUSG00000024270 (Mm), ENSRNOG00000028703 (Rn)
UniProtKB AC	Q13433 (Hs), Q8C145 (Mm), Q4V887 (Rn)
Bioparadigms SLC Tables	SLC39A6 (Hs)
RESOLUTE	SLC39A6 (Hs)
Comment	SLC39A6 (LIV-1) is a novel immuno-oncology drug target. An antibody-drug conjugate coded SGN-LIV1A is a Phase 1 clinical candidate for LIV-1-expressing tumours, in particular for triple negative breast cancers- see NCT03310957.

ZIP7 (Zinc transporter 7 / SLC39A7) Show summary »« Hide summary

Target Id	1186
Nomenclature	Zinc transporter 7
Systematic nomenclature	SLC39A7
Common abbreviation	ZIP7
Previous and unofficial names	Histidine-rich membrane protein \| solute carrier family 39 (zinc transporter), member 7 \| H-2Ke4 \| H2-KE4 \| RING5 \| solute carrier family 39 (zinc transporter)
Genes	SLC39A7 (Hs), Slc39a7 (Mm), Slc39a7 (Rn)
Ensembl ID	ENSG00000112473 (Hs), ENSMUSG00000024327 (Mm), ENSRNOG00000000465 (Rn)
UniProtKB AC	Q92504 (Hs), Q31125 (Mm)
Bioparadigms SLC Tables	SLC39A7 (Hs)
RESOLUTE	SLC39A7 (Hs)

ZIP8 (Zinc transporter 8 / SLC39A8) C Show summary »« Hide summary

Target Id

1187

Nomenclature

Zinc transporter 8

Systematic nomenclature

SLC39A8

Common abbreviation

ZIP8

Previous and unofficial names

BIGM103 | solute carrier family 39 (metal ion transporter), member 8 | zrt- and Irt-like protein 8 | solute carrier family 39 (zinc transporter), member 8 | solute carrier family 39 (metal ion transporter)

Genes

SLC39A8 (Hs), Slc39a8 (Mm), Slc39a8 (Rn)

Ensembl ID

ENSG00000138821 (Hs), ENSMUSG00000053897 (Mm), ENSRNOG00000012508 (Rn)

UniProtKB AC

Q9C0K1 (Hs), Q91W10 (Mm), Q5FVQ0 (Rn)

Bioparadigms SLC Tables

SLC39A8 (Hs)

RESOLUTE

SLC39A8 (Hs)

Substrates

Cd²⁺ [1,4]

Stoichiometry

1 Zn²⁺ (in) : 2 HCO₃^- (in) [4]

Comment

Essential for manganese (Mn) homeostasis; reclaims Mn from bile and is important for Mn uptake in the brain [3].

ZIP9 (Zinc transporter 9 / SLC39A9) Show summary »« Hide summary

Target Id	1188
Nomenclature	Zinc transporter 9
Systematic nomenclature	SLC39A9
Common abbreviation	ZIP9
Previous and unofficial names	zrt- and Irt-like protein 9 \| solute carrier family 39 (zinc transporter), member 9 \| solute carrier family 39, member 9 \| solute carrier family 39 \| solute carrier family 39 (zinc transporter)
Genes	SLC39A9 (Hs), Slc39a9 (Mm), Slc39a9 (Rn)
Ensembl ID	ENSG00000029364 (Hs), ENSMUSG00000048833 (Mm), ENSRNOG00000005052 (Rn)
UniProtKB AC	Q9NUM3 (Hs), Q8BFU1 (Mm), Q3KR82 (Rn)
Bioparadigms SLC Tables	SLC39A9 (Hs)
RESOLUTE	SLC39A9 (Hs)

ZIP10 (Zinc transporter 10 / SLC39A10) Show summary »« Hide summary

Target Id	1189
Nomenclature	Zinc transporter 10
Systematic nomenclature	SLC39A10
Common abbreviation	ZIP10
Previous and unofficial names	solute carrier family 39 (zinc transporter), member 10 \| solute carrier family 39 (zinc transporter)
Genes	SLC39A10 (Hs), Slc39a10 (Mm), Slc39a10 (Rn)
Ensembl ID	ENSG00000196950 (Hs), ENSMUSG00000025986 (Mm), ENSRNOG00000011677 (Rn)
UniProtKB AC	Q9ULF5 (Hs), Q6P5F6 (Mm)
Bioparadigms SLC Tables	SLC39A10 (Hs)
RESOLUTE	SLC39A10 (Hs)

ZIP11 (Zinc transporter 11 / SLC39A11) Show summary »« Hide summary

Target Id	1190
Nomenclature	Zinc transporter 11
Systematic nomenclature	SLC39A11
Common abbreviation	ZIP11
Previous and unofficial names	C17orf26 \| solute carrier family 39 (metal ion transporter), member 11 \| solute carrier family 39, member 11 \| solute carrier family 39 \| solute carrier family 39 (metal ion transporter)
Genes	SLC39A11 (Hs), Slc39a11 (Mm), Slc39a11 (Rn)
Ensembl ID	ENSG00000133195 (Hs), ENSMUSG00000041654 (Mm), ENSRNOG00000031213 (Rn)
UniProtKB AC	Q8N1S5 (Hs), Q8BWY7 (Mm), Q6P6S2 (Rn)
Bioparadigms SLC Tables	SLC39A11 (Hs)
RESOLUTE	SLC39A11 (Hs)

ZIP12 (Zinc transporter 12 / SLC39A12) Show summary »« Hide summary

Target Id	1191
Nomenclature	Zinc transporter 12
Systematic nomenclature	SLC39A12
Common abbreviation	ZIP12
Previous and unofficial names	solute carrier family 39 (metal ion transporter), member 12 \| solute carrier family 39 (zinc transporter), member 12 \| solute carrier family 39 (zinc transporter)
Genes	SLC39A12 (Hs), Slc39a12 (Mm), Slc39a12 (Rn)
Ensembl ID	ENSG00000148482 (Hs), ENSMUSG00000036949 (Mm), ENSRNOG00000025639 (Rn)
UniProtKB AC	Q504Y0 (Hs), Q5FWH7 (Mm)
Bioparadigms SLC Tables	SLC39A12 (Hs)
RESOLUTE	SLC39A12 (Hs)

ZIP13 (Zinc transporter 13 / SLC39A13) Show summary »« Hide summary

Target Id	1192
Nomenclature	Zinc transporter 13
Systematic nomenclature	SLC39A13
Common abbreviation	ZIP13
Previous and unofficial names	solute carrier family 39 (metal ion transporter), member 13 \| zrt- and Irt-like protein 13 \| solute carrier family 39 (zinc transporter), member 13 \| solute carrier family 39 (metal ion transporter)
Genes	SLC39A13 (Hs), Slc39a13 (Mm), Slc39a13 (Rn)
Ensembl ID	ENSG00000165915 (Hs), ENSMUSG00000002105 (Mm), ENSRNOG00000011981 (Rn)
UniProtKB AC	Q96H72 (Hs), Q8BZH0 (Mm), Q2M1K6 (Rn)
Bioparadigms SLC Tables	SLC39A13 (Hs)
RESOLUTE	SLC39A13 (Hs)

ZIP14 (Zinc transporter 14 / SLC39A14) C Show summary »« Hide summary

Target Id

1193

Nomenclature

Zinc transporter 14

Systematic nomenclature

SLC39A14

Common abbreviation

ZIP14

Previous and unofficial names

solute carrier family 39 (metal ion transporter), member 14 | NET34 | solute carrier family 39 (zinc transporter), member 14 | solute carrier family 39 (zinc transporter)

Genes

SLC39A14 (Hs), Slc39a14 (Mm), Slc39a14 (Rn)

Ensembl ID

ENSG00000104635 (Hs), ENSMUSG00000022094 (Mm), ENSRNOG00000009832 (Rn)

UniProtKB AC

Q15043 (Hs), Q75N73 (Mm)

Bioparadigms SLC Tables

SLC39A14 (Hs)

RESOLUTE

SLC39A14 (Hs)

Substrates

Cd²⁺ [2]

Fe²⁺ [5]

Mn²⁺ [2]

Comments

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References

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1. Dalton TP, He L, Wang B, Miller ML, Jin L, Stringer KF, Chang X, Baxter CS, Nebert DW. (2005) Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis. Proc Natl Acad Sci USA, 102 (9): 3401-6. [PMID:15722412]

2. Girijashanker K, He L, Soleimani M, Reed JM, Li H, Liu Z, Wang B, Dalton TP, Nebert DW. (2008) Slc39a14 gene encodes ZIP14, a metal/bicarbonate symporter: similarities to the ZIP8 transporter. Mol Pharmacol, 73 (5): 1413-23. [PMID:18270315]

3. Liu Q, Jenkitkasemwong S, Prami TA, McCabe SM, Zhao N, Hojyo S, Fukada T, Knutson MD. (2023) Metal-ion transporter SLC39A8 is required for brain manganese uptake and accumulation. J Biol Chem, 299 (8): 105078. [PMID:37482277]

4. Liu Z, Li H, Soleimani M, Girijashanker K, Reed JM, He L, Dalton TP, Nebert DW. (2008) Cd2+ versus Zn2+ uptake by the ZIP8 HCO3--dependent symporter: kinetics, electrogenicity and trafficking. Biochem Biophys Res Commun, 365 (4): 814-20. [PMID:18037372]

5. Liuzzi JP, Aydemir F, Nam H, Knutson MD, Cousins RJ. (2006) Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells. Proc Natl Acad Sci USA, 103 (37): 13612-7. [PMID:16950869]

NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Transporters. Br J Pharmacol. 180 Suppl 2:S374-469.

SLC39 family of metal ion transporters C

Overview

Transporters

Comments

Further reading

References

NC-IUPHAR subcommittee and family contributors

How to cite this family page