Arginase II

Target id: 1245

Nomenclature: Arginase II

Abbreviated Name: ARG2

Family: Arginase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Arginase II has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - ARG2 arginase 2
Mouse - - Arg2 arginase type II
Rat - - Arg2 arginase 2
Previous and Unofficial Names
AII type II arginase | arginase 2 | kidney-type arginase | non-hepatic arginase | Mitochondrial arginase
Database Links
BRENDA
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
SynPHARM
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of human Arginase-2 complexed with inhibitor 9.
PDB Id:  4HZE
Ligand:  compound 9 [PMID: 23472952]
Resolution:  1.6Å
Species:  Human
References:  3
Enzyme Reaction
EC Number: 3.5.3.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
2(S)-amino-6-boronohexanoic acid Hs Inhibition 8.1 pKi 2
pKi 8.1 (Ki 8.5x10-9 M) [2]
compound 9 [PMID: 23472952] Hs Inhibition 6.3 pIC50 3
pIC50 6.3 (IC50 5.09x10-7 M) [3]
Immunopharmacology Comments
The role of ARG2 in immuno-oncology is reviewed in [1].
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  innate immune response (GO:0045087) IEA
References: 
Immuno Process:  T cell (activation)
Immuno Process ID:  4
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  adaptive immune response (GO:0002250) IEA
negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process (GO:1905403) IEA
negative regulation of CD4-positive, alpha-beta T cell proliferation (GO:2000562) IEA
References: 
Immuno Process:  B cell (activation)
Immuno Process ID:  5
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  adaptive immune response (GO:0002250) IEA
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  negative regulation of type 2 immune response (GO:0002829) IEA
negative regulation of CD4-positive, alpha-beta T cell proliferation (GO:2000562) IEA
References: 
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  negative regulation of tumor necrosis factor production (GO:0032720) IMP
regulation of interleukin-1 beta secretion (GO:0050706) IEA
negative regulation of macrophage inflammatory protein 1 alpha production (GO:0071641) IEA
negative regulation of chemokine (C-C motif) ligand 4 production (GO:0071644) IEA
negative regulation of chemokine (C-C motif) ligand 5 production (GO:0071650) IEA
negative regulation of tumor necrosis factor secretion (GO:1904468) IEA
negative regulation of interleukin-17 secretion (GO:1905077) IEA
negative regulation of interleukin-13 secretion (GO:2000666) IEA
References: 
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  negative regulation of tumor necrosis factor production (GO:0032720) IMP
regulation of interleukin-1 beta secretion (GO:0050706) IEA
negative regulation of macrophage inflammatory protein 1 alpha production (GO:0071641) IEA
negative regulation of chemokine (C-C motif) ligand 4 production (GO:0071644) IEA
negative regulation of chemokine (C-C motif) ligand 5 production (GO:0071650) IEA
negative regulation of tumor necrosis factor secretion (GO:1904468) IEA
negative regulation of interleukin-17 secretion (GO:1905077) IEA
negative regulation of interleukin-13 secretion (GO:2000666) IEA
References: 
Immuno Process:  Chemotaxis & migration
Immuno Process ID:  10
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  negative regulation of macrophage inflammatory protein 1 alpha production (GO:0071641) IEA
negative regulation of chemokine (C-C motif) ligand 4 production (GO:0071644) IEA
negative regulation of chemokine (C-C motif) ligand 5 production (GO:0071650) IEA
negative regulation of CD4-positive, alpha-beta T cell proliferation (GO:2000562) IEA
References: 
Immuno Process:  Cellular signalling
Immuno Process ID:  11
Comment: 
GO Annotation:  Associated to GO processes, IEA only
GO Processes:  negative regulation of CD4-positive, alpha-beta T cell proliferation (GO:2000562) IEA
References: 

References

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1. Adams JL, Smothers J, Srinivasan R, Hoos A. (2015) Big opportunities for small molecules in immuno-oncology. Nat Rev Drug Discov14 (9): 603-22. [PMID:26228631]

2. Colleluori DM, Ash DE. (2001) Classical and slow-binding inhibitors of human type II arginase. Biochemistry40 (31): 9356-62. [PMID:11478904]

3. Van Zandt MC, Whitehouse DL, Golebiowski A, Ji MK, Zhang M, Beckett RP, Jagdmann GE, Ryder TR, Sheeler R, Andreoli M et al.. (2013) Discovery of (R)-2-amino-6-borono-2-(2-(piperidin-1-yl)ethyl)hexanoic acid and congeners as highly potent inhibitors of human arginases I and II for treatment of myocardial reperfusion injury. J. Med. Chem.56 (6): 2568-80. [PMID:23472952]

How to cite this page

Arginase: Arginase II. Last modified on 16/03/2017. Accessed on 11/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1245.