Inducible NOS

Target id: 1250

Nomenclature: Inducible NOS

Abbreviated Name: iNOS

Family: Nitric oxide synthases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Inducible NOS has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - NOS2 nitric oxide synthase 2
Mouse - - Nos2 nitric oxide synthase 2, inducible
Rat - - Nos2 nitric oxide synthase 2
Previous and Unofficial Names
NOS2A | HEP-NOS | nitric oxide synthase 2A (inducible, hepatocytes) | Nitric oxide synthase 2 inducible | Nitric oxide synthase 2 inducible macrophage | inducible NO synthase | Nitric oxide synthase 2 / NOSII | inducible macrophage NOS | nitric oxide synthase 2
Database Links
BRENDA
CATH/Gene3D
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.14.13.39
Products
Product Species Reference
NO Human
L-citrulline Human
Cofactors
Cofactor Species Comments Reference
Zn2+ Human
NADPH Human
heme Human
flavin adenine dinucleotide Human
flavin mononucleotide Human
BH4 Human
oxygen Human
Endogenous Substrate (Human)
L-arginine

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
L-NNA Hs Inhibition 6.2 pKi 2
pKi 6.2 (Ki 6.7x10-7 M) [2]
GW274150 Hs Inhibition 7.2 pIC50 3
pIC50 7.2 (IC50 7x10-8 M) [3]
Immunopharmacology Comments
The role of iNOS in immuno-oncology is reviewed in [1].
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0002227 innate immune response in mucosa NAS
GO:1900015 regulation of cytokine production involved in inflammatory response IDA
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GO:0071346 cellular response to interferon-gamma IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:1900015 regulation of cytokine production involved in inflammatory response IDA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 4 GO processes
GO:0072604 interleukin-6 secretion IDA
GO:0072606 interleukin-8 secretion IDA
GO:1900015 regulation of cytokine production involved in inflammatory response IDA
click arrow to show/hide IEA associations
GO:0071346 cellular response to interferon-gamma IEA

References

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1. Adams JL, Smothers J, Srinivasan R, Hoos A. (2015) Big opportunities for small molecules in immuno-oncology. Nat Rev Drug Discov, 14 (9): 603-22. [PMID:26228631]

2. Collins JL, Shearer BG, Oplinger JA, Lee S, Garvey EP, Salter M, Duffy C, Burnette TC, Furfine ES. (1998) N-Phenylamidines as selective inhibitors of human neuronal nitric oxide synthase: structure-activity studies and demonstration of in vivo activity. J. Med. Chem., 41 (15): 2858-71. [PMID:9667974]

3. Connolly S, Aberg A, Arvai A, Beaton HG, Cheshire DR, Cook AR, Cooper S, Cox D, Hamley P, Mallinder P et al.. (2004) 2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution. J. Med. Chem., 47 (12): 3320-3. [PMID:15163211]

Contributors

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How to cite this page

Andreas Papapetropoulos, Csaba Szabo, Timothy R. Billiar, Giuseppe Cirino, David Fulton, Roberto Motterlini.
Nitric oxide synthases: Inducible NOS. Last modified on 16/03/2018. Accessed on 24/06/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1250.