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protein arginine methyltransferase 7

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Target not currently curated in GtoImmuPdb

Target id: 1258

Nomenclature: protein arginine methyltransferase 7

Abbreviated Name: PRMT7

Family: 2.1.1.- Protein arginine N-methyltransferases

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 692 16q22.1 PRMT7 protein arginine methyltransferase 7
Mouse - 692 8 D3 Prmt7 protein arginine N-methyltransferase 7
Rat - 693 19q12 Prmt7 protein arginine methyltransferase 7
Previous and Unofficial Names Click here for help
[Myelin basic protein]-arginine N-methyltransferase PRMT7
Database Links Click here for help
Alphafold Q9NVM4 (Hs), Q922X9 (Mm), Q5U4E8 (Rn)
BRENDA 2.1.1.125, 2.1.1.126
ChEMBL Target CHEMBL3562175 (Hs)
Ensembl Gene ENSG00000132600 (Hs), ENSMUSG00000060098 (Mm), ENSRNOG00000000258 (Rn)
Entrez Gene 54496 (Hs), 214572 (Mm), 361402 (Rn)
Human Protein Atlas ENSG00000132600 (Hs)
KEGG Enzyme 2.1.1.125, 2.1.1.126
KEGG Gene hsa:54496 (Hs), mmu:214572 (Mm), rno:361402 (Rn)
OMIM 610087 (Hs)
Pharos Q9NVM4 (Hs)
UniProtKB Q9NVM4 (Hs), Q922X9 (Mm), Q5U4E8 (Rn)
Wikipedia PRMT7 (Hs)
Enzyme Reaction Click here for help
EC Number: 2.1.1.125
EC Number: 2.1.1.126

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
DS-437 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Hs Inhibition 5.2 pIC50 1
⤷ pIC50 5.2 (IC50 6x10-6 M) [1]

References

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1. Smil D, Eram MS, Li F, Kennedy S, Szewczyk MM, Brown PJ, Barsyte-Lovejoy D, Arrowsmith CH, Vedadi M, Schapira M. (2015) Discovery of a Dual PRMT5-PRMT7 Inhibitor. ACS Med Chem Lett, 6 (4): 408-12. [PMID:25893041]

How to cite this page

2.1.1.- Protein arginine N-methyltransferases: protein arginine methyltransferase 7 . Last modified on 13/08/2015. Accessed on 20/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1258.