γ-Glutamyl carboxylase

Target id: 1268

Nomenclature: γ-Glutamyl carboxylase

Abbreviated Name: GGCX

Family: Carboxylases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for γ-Glutamyl carboxylase in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 758 2p12 GGCX gamma-glutamyl carboxylase
Mouse - 757 6 32.27 cM Ggcx gamma-glutamyl carboxylase
Rat - 758 4q33 Ggcx gamma-glutamyl carboxylase
Previous and Unofficial Names
vitamin K-dependent gamma-carboxylase | peptidyl-glutamate 4-carboxylase | vitamin K gamma glutamyl carboxylase | VKCFD1
Database Links
BRENDA
CATH/Gene3D
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 4.1.1.90
Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
glutamyl peptides Hs - -
Cofactors
Cofactor Species Comments Reference
NADPH Human
vitamin K hydroquinone Human

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
anisindione Hs Inhibition - -
Clinically-Relevant Mutations and Pathophysiology
Disease:  Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency
Synonyms: Body skin hyperlaxity due to vitamin K-dependent coagulation factor deficiency [Orphanet: ORPHA91135]
OMIM: 610842
Orphanet: ORPHA91135
Disease:  Vitamin K-dependent clotting factors, combined deficiency of, 1; VKCFD1
Synonyms: Hereditary combined deficiency of vitamin K-dependent clotting factors [Orphanet: ORPHA98434]
OMIM: 277450
Orphanet: ORPHA98434

How to cite this page

Carboxylases: γ-Glutamyl carboxylase. Last modified on 14/02/2017. Accessed on 20/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1268.