<i>GPR135</i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

GPR135

Target id: 129

Nomenclature: GPR135

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for GPR135 in GtoImmuPdb

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 494 14q22.3 GPR135 G protein-coupled receptor 135
Mouse 7 457 12 C3 Gpr135 G protein-coupled receptor 135
Rat 7 457 6q24 Gpr135 G protein-coupled receptor 135
Previous and Unofficial Names
HUMNPIIY20 | PAFR
Database Links
Specialist databases
GPCRDB gp135_human (Hs), gp135_mouse (Mm), gp135_rat (Rn)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Tissue Distribution
Neuron, stomach, eye, cervix, testis
Species:  Human
Technique:  Expressed sequence tag
References:  1
Pituitary
Species:  Human
Technique:  Northern Blot
References:  2
Expression Datasets

Show »

Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

There should be a chart of expression data here, you may need to enable JavaScript!
Biologically Significant Variants
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  S191N
Global MAF (%):  1
Subpopulation MAF (%):  ASN: 3
Minor allele count:  T=0.007/16
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 
Validation:  1000 Genomes
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  V481A
Global MAF (%):  2
Subpopulation MAF (%):  AFR: 9
Minor allele count:  G=0.020/44
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 
Validation:  1000 Genomes, HapMap, Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  Q5P
Global MAF (%):  47
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 53|24|45|55
Minor allele count:  G=0.468/1023
SNP accession: 
Validation:  1000 Genomes

References

Show »

1. Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB. (2003) Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett., 554 (3): 381-8. [PMID:14623098]

2. Vanti WB, Nguyen T, Cheng R, Lynch KR, George SR, O'Dowd BF. (2003) Novel human G-protein-coupled receptors. Biochem Biophys Res Commun, 305: 67-71. [PMID:12732197]

Contributors

Show »

How to cite this page

Anthony P. Davenport, Stephen Alexander, Joanna L. Sharman, Adam J. Pawson, Helen E. Benson, Amy E. Monaghan, Wen Chiy Liew, Chido Mpamhanga, Jim Battey, Richard V. Benya, Robert T. Jensen, Sadashiva Karnik, Evi Kostenis, Eliot Spindel, Laura Storjohann, Kalyan Tirupula, Tom I. Bonner, Richard Neubig, Jean-Philippe Pin, Michael Spedding, Anthony Harmar.
Class A Orphans: GPR135. Last modified on 16/06/2015. Accessed on 13/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=129.