phosphodiesterase 7B

Target id: 1306

Nomenclature: phosphodiesterase 7B

Abbreviated Name: PDE7B

Family: Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs)

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for phosphodiesterase 7B in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 450 6q23-q24 PDE7B phosphodiesterase 7B
Mouse - 446 10 9.75cM Pde7b phosphodiesterase 7B
Rat - - 1p12 Pde7b phosphodiesterase 7B
Previous and Unofficial Names
cAMP-specific 3',5'-cyclic phosphodiesterase 7B
Database Links
BRENDA
CATH/Gene3D
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.1.4.17
Rank order of affinity (Human)
cyclic AMP >> cyclic GMP  [2]

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
dipyridamole Hs Inhibition 5.7 – 6.0 pIC50 2-3
pIC50 5.7 – 6.0 (IC50 1.99x10-6 – 1x10-6 M) [2-3]
SCH51866 Hs Inhibition 5.8 pIC50 3
pIC50 5.8 (IC50 1.58x10-6 M) [3]
BRL50481 Hs Inhibition 4.9 pIC50 1
pIC50 4.9 [1]

References

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1. Alaamery MA, Wyman AR, Ivey FD, Allain C, Demirbas D, Wang L, Ceyhan O, Hoffman CS. (2010) New classes of PDE7 inhibitors identified by a fission yeast-based HTS. J Biomol Screen15 (4): 359-67. [PMID:20228279]

2. Gardner C, Robas N, Cawkill D, Fidock M. (2000) Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase. Biochem. Biophys. Res. Commun.272 (1): 186-92. [PMID:10872825]

3. Sasaki T, Kotera J, Yuasa K, Omori K. (2000) Identification of human PDE7B, a cAMP-specific phosphodiesterase. Biochem. Biophys. Res. Commun.271 (3): 575-83. [PMID:10814504]

How to cite this page

Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs): phosphodiesterase 7B. Last modified on 10/06/2016. Accessed on 21/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1306.