CYP1A1

Target id: 1318

Nomenclature: CYP1A1

Family: CYP1 family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for CYP1A1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - CYP1A1 cytochrome P450 family 1 subfamily A member 1
Mouse - - Cyp1a1 cytochrome P450
Rat - - Cyp1a1 cytochrome P450
Previous and Unofficial Names
Aryl hydrocarbon hydroxylase | CP11 | AHH | AHRR | Cyp45c | Cypc45c | cytochrome P450 1A1 | microsomal monooxygenase | xenobiotic monooxygenase | cytochrome P450 subfamily I, polypeptide 1 | cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1 | cytochrome P450, family 1, subfamily A, polypeptide 1 | cytochrome P450, family 1, subfamily a, polypeptide 1 | cytochrome P450
Database Links
BRENDA
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.14.1.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
chrysin Hs Inhibition 7.4 pKi 1
pKi 7.4 (Ki 4.2x10-8 M) [1]
5H3'FPE Hs Inhibition 7.4 pIC50 2
pIC50 7.4 (IC50 4.3x10-8 M) [2]

References

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1. Androutsopoulos VP, Papakyriakou A, Vourloumis D, Spandidos DA. (2011) Comparative CYP1A1 and CYP1B1 substrate and inhibitor profile of dietary flavonoids. Bioorg. Med. Chem.19 (9): 2842-9. [PMID:21482471]

2. Liu J, Taylor SF, Dupart PS, Arnold CL, Sridhar J, Jiang Q, Wang Y, Skripnikova EV, Zhao M, Foroozesh M. (2013) Pyranoflavones: a group of small-molecule probes for exploring the active site cavities of cytochrome P450 enzymes 1A1, 1A2, and 1B1. J. Med. Chem.56 (10): 4082-92. [PMID:23600958]

How to cite this page

CYP1 family: CYP1A1. Last modified on 17/09/2015. Accessed on 17/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1318.