CYP2B6 | CYP2 family | IUPHAR/BPS Guide to PHARMACOLOGY

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CYP2B6

Target not currently curated in GtoImmuPdb

Target id: 1324

Nomenclature: CYP2B6

Family: CYP2 family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - CYP2B6 cytochrome P450 family 2 subfamily B member 6
Previous and Unofficial Names
cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6 | 1,4-cineole 2-exo-monooxygenase | cytochrome P450, family 2, subfamily B, polypeptide 6
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.14.14.1

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Parameter Reference
thiotepa Hs Inhibition 5.3 pKi 3
pKi 5.3 (Ki 4.8x10-6 M) [3]
ticlopidine Hs Inhibition 6.7 pIC50 2
pIC50 6.7 (IC50 2x10-7 M) [2]
sibutramine Hs Inhibition 5.8 pIC50 1
pIC50 5.8 (IC50 1.61x10-6 M) [1]

References

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1. Bae SH, Kwon MJ, Choi EJ, Zheng YF, Yoon KD, Liu KH, Bae SK. (2013) Potent inhibition of cytochrome P450 2B6 by sibutramine in human liver microsomes. Chem. Biol. Interact., 205 (1): 11-9. [PMID:23777987]

2. Fontana E, Dansette PM, Poli SM. (2005) Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Curr. Drug Metab., 6 (5): 413-54. [PMID:16248836]

3. Walsky RL, Obach RS. (2007) A comparison of 2-phenyl-2-(1-piperidinyl)propane (ppp), 1,1',1''-phosphinothioylidynetrisaziridine (thioTEPA), clopidogrel, and ticlopidine as selective inactivators of human cytochrome P450 2B6. Drug Metab. Dispos., 35 (11): 2053-9. [PMID:17682072]

How to cite this page

CYP2 family: CYP2B6. Last modified on 01/02/2019. Accessed on 21/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1324.