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GPR146

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Target not currently curated in GtoImmuPdb

Target id: 133

Nomenclature: GPR146

Family: Class A Orphans

This receptor has a proposed ligand; see the Latest Pairings page for more information.

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 333 7p22.3 GPR146 G protein-coupled receptor 146
Mouse 7 333 5 G2 Gpr146 G protein-coupled receptor 146
Rat 7 333 12q11 Gpr146 G protein-coupled receptor 146
Previous and Unofficial Names Click here for help
AXOR120 | G-protein coupled receptor PGR8
Database Links Click here for help
Specialist databases
GPCRdb gp146_human (Hs)
Other databases
Alphafold Q96CH1 (Hs), Q99LE2 (Mm)
ChEMBL Target CHEMBL4523904 (Hs)
Ensembl Gene ENSG00000164849 (Hs), ENSMUSG00000044197 (Mm), ENSRNOG00000001288 (Rn)
Entrez Gene 115330 (Hs), 80290 (Mm), 498153 (Rn)
Human Protein Atlas ENSG00000164849 (Hs)
KEGG Gene hsa:115330 (Hs), mmu:80290 (Mm), rno:498153 (Rn)
Pharos Q96CH1 (Hs)
RefSeq Nucleotide NM_138445 (Hs), NM_030258 (Mm), NM_001109062 (Rn)
RefSeq Protein NP_612454 (Hs), NP_084534 (Mm), NP_001102532 (Rn)
UniProtKB Q96CH1 (Hs), Q99LE2 (Mm)
Wikipedia GPR146 (Hs)
Agonist Comments
Yosten et al. demonstrated inhibition of proinsulin C-peptide-induced stimulation of cFos expression folllowing knockdown of GPR146 in KATOIII cells, suggesting proinsulin C-peptide as an endogenous ligand of the receptor [1].
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants Click here for help
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  G11E
SNP accession:  rs11761941
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  V266M
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession:  rs55677825

References

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1. Yosten GL, Kolar GR, Redlinger LJ, Samson WK. (2013) Evidence for an interaction between proinsulin C-peptide and GPR146. J Endocrinol, 218 (2): B1-8. [PMID:23759446]

Contributors

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