CYP11A1

Target id: 1358

Nomenclature: CYP11A1

Family: CYP11, CYP17, CYP19, CYP20 and CYP21 families

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for CYP11A1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 521 15q23-q24 CYP11A1 cytochrome P450 family 11 subfamily A member 1
Mouse - 526 9 31.63 cM Cyp11a1 cytochrome P450
Rat - 526 8q24 Cyp11a1 cytochrome P450
Previous and Unofficial Names
cholesterol desmolase | cholesterol monooxygenase (side-chain-cleaving) | cytochrome P450 11A1 | cytochrome P450, family 11, subfamily a, polypeptide 1 | cytochrome P450, family 11, subfamily A, polypeptide 1 | cytochrome P450
Database Links
BRENDA
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.14.15.6

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
aminoglutethimide Ma Inhibition 4.5 pIC50 1
pIC50 4.5 (IC50 3x10-5 M) [1]
Description: Measuring inhibition of progesterone synthesis in hamster ovarian slices as an indicatior of CYP11A1 activity.
mitotane Hs Inhibition - - 2-3
[2-3]
View species-specific inhibitor tables
Clinically-Relevant Mutations and Pathophysiology
Disease:  Adrenal insufficiency, congenital, with 46,XY sex reversal, partial or complete
Synonyms: 46,XY disorder of sex development - adrenal insufficiency due to CYP11A1 deficiency [Orphanet: ORPHA168558]
Congenital adrenal insufficiency [Disease Ontology: DOID:0050546]
Disease Ontology: DOID:0050546
OMIM: 613743
Orphanet: ORPHA168558
Disease:  Inherited isolated adrenal insufficiency due to CYP11A1 deficiency
Orphanet: ORPHA289548

References

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1. Browne LJ, Gude C, Rodriguez H, Steele RE, Bhatnager A. (1991) Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease. J. Med. Chem.34 (2): 725-36. [PMID:1825337]

2. Lehmann TP, Wrzesiński T, Jagodziński PP. (2013) The effect of mitotane on viability, steroidogenesis and gene expression in NCI‑H295R adrenocortical cells. Mol Med Rep7 (3): 893-900. [PMID:23254310]

3. Libè R, Fratticci A, Bertherat J. (2007) Adrenocortical cancer: pathophysiology and clinical management. Endocr. Relat. Cancer14 (1): 13-28. [PMID:17395972]

How to cite this page

CYP11, CYP17, CYP19, CYP20 and CYP21 families: CYP11A1. Last modified on 22/10/2015. Accessed on 11/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1358.