CYP17A1

Target id: 1361

Nomenclature: CYP17A1

Family: CYP11, CYP17, CYP19, CYP20 and CYP21 families

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for CYP17A1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 508 10q24.3 CYP17A1 cytochrome P450 family 17 subfamily A member 1
Mouse - 507 19 38.97 cM Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1
Rat - 507 1q55 Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1
Previous and Unofficial Names
Steroid 17-α-hydroxylase/17,20 lyase | cytochrome P450 17A1 | steroid 17-alpha hydroxylase | cytochrome P450, family 17, subfamily a, polypeptide 1 | cytochrome P450, family 17, subfamily A, polypeptide 1 | cytochrome P450
Database Links
BRENDA
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
SynPHARM
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.14.99.9

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
abiraterone Hs Inhibition 7.1 – 8.4 pIC50 2-3
pIC50 7.1 – 8.4 [2-3]
galeterone Hs Inhibition 6.5 pIC50 1
pIC50 6.5 (IC50 3x10-7 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  46,XY disorder of sex development due to isolated 17, 20 lyase deficiency
Synonyms: 46 XY gonadal dysgenesis [Disease Ontology: DOID:14448]
Disease Ontology: DOID:14448
OMIM: 614279
Orphanet: ORPHA90796
Disease:  Congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency
Synonyms: Congenital adrenal hyperplasia [Disease Ontology: DOID:12255]
Disease Ontology: DOID:12255
OMIM: 202110
Orphanet: ORPHA90793

References

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1. Handratta VD, Vasaitis TS, Njar VC, Gediya LK, Kataria R, Chopra P, Newman Jr D, Farquhar R, Guo Z, Qiu Y et al.. (2005) Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model. J. Med. Chem.48 (8): 2972-84. [PMID:15828836]

2. Pinto-Bazurco Mendieta MA, Negri M, Jagusch C, Müller-Vieira U, Lauterbach T, Hartmann RW. (2008) Synthesis, biological evaluation, and molecular modeling of abiraterone analogues: novel CYP17 inhibitors for the treatment of prostate cancer. J. Med. Chem.51 (16): 5009-18. [PMID:18672868]

3. Potter GA, Barrie SE, Jarman M, Rowlands MG. (1995) Novel steroidal inhibitors of human cytochrome P45017 alpha (17 alpha-hydroxylase-C17,20-lyase): potential agents for the treatment of prostatic cancer. J. Med. Chem.38 (13): 2463-71. [PMID:7608911]

How to cite this page

CYP11, CYP17, CYP19, CYP20 and CYP21 families: CYP17A1. Last modified on 28/07/2015. Accessed on 23/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1361.