<i>GPR151</i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

GPR151

Target id: 137

Nomenclature: GPR151

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for GPR151 in GtoImmuPdb

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 419 5q32 GPR151 G protein-coupled receptor 151
Mouse 7 422 18 B3 Gpr151 G protein-coupled receptor 151
Rat 7 421 18p11 Gpr151 G protein-coupled receptor 151
Previous and Unofficial Names
GALR4 | G-protein coupled receptor PGR7 | galanin receptor 4
Database Links
Specialist databases
GPCRDB gp151_human (Hs), gp151_mouse (Mm), gp151_rat (Rn)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Agonist Comments
GPR151 responded to galanin with an EC50 value of 2 uM. This suggests that the endogenous ligand shares structural features with galanin [1].
Tissue Distribution
Spinal cord, brain, peripheral organs and tissues such as testis, liver, kidney and stomach
Species:  Human
Technique:  Northern blot
References:  1
Spinal cord, brain, peripheral organs and tissues such as testis, liver, kidney and stomach
Species:  Mouse
Technique:  Northern blot
References:  1
Central nervous system and habenular complex
Species:  Mouse
Technique:  in situ hybridisation
References:  1
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Gpr151tm1Dgen Gpr151tm1Dgen/Gpr151tm1Dgen
involves: 129P2/OlaHsd * C57BL/6
MGI:2441887  MP:0002169 no abnormal phenotype detected
Biologically Significant Variants
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  L261V
Global MAF (%):  36
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 23|22|80|19
Minor allele count:  C=0.363/792
SNP accession: 
Validation:  1000 Genomes, HapMap, Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  P40L
Global MAF (%):  4
Subpopulation MAF (%):  AFR|AMR|EUR: 4|7|7
Minor allele count:  A=0.044/97
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 
Validation:  1000 Genomes, HapMap, Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  A144V
Global MAF (%):  7
Subpopulation MAF (%):  AFR|AMR|ASN: 18|7|6
Minor allele count:  A=0.067/147
SNP accession: 
Validation:  1000 Genomes, HapMap, Frequency
General Comments
Both human and mouse GPR151 lack the well-conserved D-R-Y motif downstream of the third transmembrane domain [1].

References

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1. Ignatov A, Hermans-Borgmeyer I, Schaller HC. (2004) Cloning and characterization of a novel G-protein-coupled receptor with homology to galanin receptors. Neuropharmacology, 46 (8): 1114-20. [PMID:15111018]

Contributors

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How to cite this page

Anthony P. Davenport, Stephen Alexander, Joanna L. Sharman, Adam J. Pawson, Helen E. Benson, Amy E. Monaghan, Wen Chiy Liew, Chido Mpamhanga, Jim Battey, Richard V. Benya, Robert T. Jensen, Sadashiva Karnik, Evi Kostenis, Eliot Spindel, Laura Storjohann, Kalyan Tirupula, Tom I. Bonner, Richard Neubig, Jean-Philippe Pin, Michael Spedding, Anthony Harmar.
Class A Orphans: GPR151. Last modified on 16/06/2015. Accessed on 17/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=137.