15-LOX-1

Target id: 1388

Nomenclature: 15-LOX-1

Family: Lipoxygenases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for 15-LOX-1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - ALOX15 arachidonate 15-lipoxygenase
Mouse - - Alox15 arachidonate 15-lipoxygenase
Rat - - Alox15 arachidonate 15-lipoxygenase
Previous and Unofficial Names
arachidonate ω-6 lipoxygenase | Alox12 | 12/15-LOX | 12-LOX | Alox12l | arachidonate 12-lipoxygenase, leukocyte-type | arachidonate 15-lipoxygenase | 12-LO
Database Links
BRENDA
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 1.13.11.33 Arachidonic acid + O2 = 15S-HPETE
Description Reaction Reference
Linoleic acid + O2 => 13S-HPODE

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 34 [PMID: 20866075] Hs Inhibition >8.0 pKi 2
pKi >8.0 (Ki <1x10-8 M) [2]
Allosteric Modulators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
PKUMDL_MH_1001 Hs Positive 5.4 pKd 1
pKd 5.4 (Kd 3.9x10-6 M) [1]
Description: Determined by surface plasmon resonance (SPR).

References

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1. Meng H, McClendon CL, Dai Z, Li K, Zhang X, He S, Shang E, Liu Y, Lai L. (2015) Discovery of Novel 15-Lipoxygenase Activators To Shift the Human Arachidonic Acid Metabolic Network toward Inflammation Resolution. J. Med. Chem.,  [Epub ahead of print]. [PMID:26290290]

2. Rai G, Kenyon V, Jadhav A, Schultz L, Armstrong M, Jameson JB, Hoobler E, Leister W, Simeonov A, Holman TR et al.. (2010) Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1. J. Med. Chem.53 (20): 7392-404. [PMID:20866075]

How to cite this page

Lipoxygenases: 15-LOX-1. Last modified on 02/05/2016. Accessed on 19/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1388.