<i>GPR153</i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

GPR153

Target id: 139

Nomenclature: GPR153

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for GPR153 in GtoImmuPdb

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 609 1p36.31 GPR153 G protein-coupled receptor 153
Mouse 7 631 4 E2 Gpr153 G protein-coupled receptor 153
Rat 7 569 5q36 Gpr153 G protein-coupled receptor 153
Previous and Unofficial Names
PGR1
Database Links
Specialist databases
GPCRDB gp153_human (Hs), gp153_mouse (Mm)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Tissue Distribution
High expression in thalamus, cerebral cortex and striatum. In the hypothalamus, expression was restricted to the arcuate and paraventricular nuclei. Moderate to high expression was detected in certain amygdaloidal regions such as posterolateral cortical amygdaloidal area, anterior cortical amygdaloidal area, anterior cortical amygdaloidal area, medial amygdaloidal area and basomedial amygdaloidal nucleus.
Species:  Mouse
Technique:  in situ hybridization
References:  1
Brainstem, cerebellum, prefrontal cortex, cortex, hypothalamus, hippocampus, eye, spinal cord, adrenal gland, skeletal muscle, heart, kidney, liver, lungs, spleen, thymus, stomach, uterus, testicle, intestine, blood, skin, choroid plexus
Species:  Rat
Technique:  RT-PCR
References:  1
Tissue Distribution Comments
Expression of GPR153 was not detected in the rat hippocampus, brain stem, ventromedial and lateral hypothalamus or basolateral amygdaloidal nucleus examined by in situ hybridization [1]. GPR153 expression pattern was found to be specific to the grey matter but lacking in the white matter [1].
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Physiological Consequences of Altering Gene Expression
In the elevated plus maze test, Gpr153 knockdown rats showed a significant reduction in the time spent in the central square which is a probable measure of decision making.
Species:  Rat
Tissue:  Cerebral ventricle
Technique:  Gene knockdown by Gpr153 antisense oligodeooxynucleotide
References:  1
Biologically Significant Variants
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  R73H
Global MAF (%):  2
Subpopulation MAF (%):  AFR|AMR: 7|1
Minor allele count:  T=0.018/39
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 
Validation:  1000 Genomes, Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  G347D
Global MAF (%):  2
Subpopulation MAF (%):  AFR|AMR: 7|1
Minor allele count:  T=0.018/39
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 
Validation:  1000 Genomes, Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  R209H
Global MAF (%):  31
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 31|23|41|28
Minor allele count:  C=0.312/682
SNP accession: 
Validation:  1000 Genomes, Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  V402M
Global MAF (%):  5
Subpopulation MAF (%):  ASN: 19
Minor allele count:  T=0.051/112
SNP accession: 
Validation:  1000 Genomes, Frequency
Type:  Naturally occurring SNP
Species:  Human
Amino acid change:  T102P
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 
General Comments
GPR153 is a cerebellar target of the Gli1 transcription factor, which is involved in the maintenance and proliferation of grabule neuron precursor cells in the cerebellum [1].

References

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1. Sreedharan S, Almén MS, Carlini VP, Haitina T, Stephansson O, Sommer WH, Heilig M, de Barioglio SR, Fredriksson R, Schiöth HB. (2011) The G protein coupled receptor Gpr153 shares common evolutionary origin with Gpr162 and is highly expressed in central regions including the thalamus, cerebellum and the arcuate nucleus. FEBS J., 278 (24): 4881-94. [PMID:21981325]

Contributors

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How to cite this page

Anthony P. Davenport, Stephen Alexander, Joanna L. Sharman, Adam J. Pawson, Helen E. Benson, Amy E. Monaghan, Wen Chiy Liew, Chido Mpamhanga, Jim Battey, Richard V. Benya, Robert T. Jensen, Sadashiva Karnik, Evi Kostenis, Eliot Spindel, Laura Storjohann, Kalyan Tirupula, Tom I. Bonner, Richard Neubig, Jean-Philippe Pin, Michael Spedding, Anthony Harmar.
Class A Orphans: GPR153. Last modified on 16/06/2015. Accessed on 15/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=139.