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GPR153

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Target not currently curated in GtoImmuPdb

Target id: 139

Nomenclature: GPR153

Family: Class A Orphans

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 609 1p36.31 GPR153 G protein-coupled receptor 153
Mouse 7 631 4 E2 Gpr153 G protein-coupled receptor 153
Rat 6 569 5q36 Gpr153 G protein-coupled receptor 153
Previous and Unofficial Names Click here for help
PGR1
Database Links Click here for help
Specialist databases
GPCRdb gp153_human (Hs), gp153_mouse (Mm)
Other databases
Alphafold Q6NV75 (Hs), Q8K0Z9 (Mm), D4ABT6 (Rn)
ChEMBL Target CHEMBL4523876 (Hs)
Ensembl Gene ENSG00000158292 (Hs), ENSMUSG00000042804 (Mm), ENSRNOG00000010718 (Rn)
Entrez Gene 387509 (Hs), 100129 (Mm), 619550 (Rn)
Human Protein Atlas ENSG00000158292 (Hs)
KEGG Gene hsa:387509 (Hs), mmu:100129 (Mm), rno:619550 (Rn)
OMIM 614269 (Hs)
Pharos Q6NV75 (Hs)
RefSeq Nucleotide NM_207370 (Hs), NM_178406 (Mm), NM_001034855 (Rn)
RefSeq Protein NP_997253 (Hs), NP_848493 (Mm), NP_001030027 (Rn)
UniProtKB Q6NV75 (Hs), Q8K0Z9 (Mm), D4ABT6 (Rn)
Wikipedia GPR153 (Hs)
Tissue Distribution Click here for help
High expression in thalamus, cerebral cortex and striatum. In the hypothalamus, expression was restricted to the arcuate and paraventricular nuclei. Moderate to high expression was detected in certain amygdaloidal regions such as posterolateral cortical amygdaloidal area, anterior cortical amygdaloidal area, anterior cortical amygdaloidal area, medial amygdaloidal area and basomedial amygdaloidal nucleus.
Species:  Mouse
Technique:  in situ hybridization
References:  1
Brainstem, cerebellum, prefrontal cortex, cortex, hypothalamus, hippocampus, eye, spinal cord, adrenal gland, skeletal muscle, heart, kidney, liver, lungs, spleen, thymus, stomach, uterus, testicle, intestine, blood, skin, choroid plexus
Species:  Rat
Technique:  RT-PCR
References:  1
Tissue Distribution Comments
Expression of GPR153 was not detected in the rat hippocampus, brain stem, ventromedial and lateral hypothalamus or basolateral amygdaloidal nucleus examined by in situ hybridization [1]. GPR153 expression pattern was found to be specific to the grey matter but lacking in the white matter [1].
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Physiological Consequences of Altering Gene Expression Click here for help
In the elevated plus maze test, Gpr153 knockdown rats showed a significant reduction in the time spent in the central square which is a probable measure of decision making.
Species:  Rat
Tissue:  Cerebral ventricle
Technique:  Gene knockdown by Gpr153 antisense oligodeooxynucleotide
References:  1
Biologically Significant Variants Click here for help
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  R73H
Global MAF (%):  2
Subpopulation MAF (%):  AFR|AMR: 7|1
Minor allele count:  T=0.018/39
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession:  rs61741782
Validation:  1000 Genomes, Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  G347D
Global MAF (%):  2
Subpopulation MAF (%):  AFR|AMR: 7|1
Minor allele count:  T=0.018/39
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession:  rs111970052
Validation:  1000 Genomes, Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  R209H
Global MAF (%):  31
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 31|23|41|28
Minor allele count:  C=0.312/682
SNP accession:  rs12735670
Validation:  1000 Genomes, Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  V402M
Global MAF (%):  5
Subpopulation MAF (%):  ASN: 19
Minor allele count:  T=0.051/112
SNP accession:  rs78132938
Validation:  1000 Genomes, Frequency
Type:  Naturally occurring SNP
Species:  Human
Amino acid change:  T102P
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession:  rs78547048
General Comments
GPR153 is a cerebellar target of the Gli1 transcription factor, which is involved in the maintenance and proliferation of grabule neuron precursor cells in the cerebellum [1].

References

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1. Sreedharan S, Almén MS, Carlini VP, Haitina T, Stephansson O, Sommer WH, Heilig M, de Barioglio SR, Fredriksson R, Schiöth HB. (2011) The G protein coupled receptor Gpr153 shares common evolutionary origin with Gpr162 and is highly expressed in central regions including the thalamus, cerebellum and the arcuate nucleus. FEBS J, 278 (24): 4881-94. [PMID:21981325]

Contributors

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