Dipeptidase 1

Target id: 1393

Nomenclature: Dipeptidase 1

Family: M19: Membrane dipeptidase, Leukotriene and lipoxin metabolism

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Dipeptidase 1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 411 16q24 DPEP1 dipeptidase 1
Mouse - 410 8 E1 Dpep1 dipeptidase 1 (renal)
Rat - 410 19q12 Dpep1 dipeptidase 1
Previous and Unofficial Names
microsomal dipeptidase | MBD | dipeptidase 1 (renal)
Database Links
Specialist databases
MEROPS M19.001 (Hs)
Other databases
BRENDA
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.13.19 LTD4 + H2O = LTE4 + glycine

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
cilastatin ? Inhibition 6.0 pKi 1
pKi 6.0 (Ki 1.1x10-6 M) [1]

References

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1. Graham DW, Ashton WT, Barash L, Brown JE, Brown RD, Canning LF, Chen A, Springer JP, Rogers EF. (1987) Inhibition of the mammalian beta-lactamase renal dipeptidase (dehydropeptidase-I) by (Z)-2-(acylamino)-3-substituted-propenoic acids. J. Med. Chem.30 (6): 1074-90. [PMID:3495664]

How to cite this page

M19: Membrane dipeptidase: Dipeptidase 1. Last modified on 12/12/2013. Accessed on 11/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1393.