<i>GPR160</i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

GPR160

Target id: 140

Nomenclature: GPR160

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for GPR160 in GtoImmuPdb

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 338 3q26.2-q27 GPR160 G protein-coupled receptor 160
Mouse 7 336 3 B Gpr160 G protein-coupled receptor 160
Rat 7 336 2q24 Gpr160 G protein-coupled receptor 160
Previous and Unofficial Names
GPCR1 | GPCR150
Database Links
Specialist databases
GPCRDB gp160_human (Hs), gp160_mouse (Mm), gp160_rat (Rn)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Functional Assays
miR-125b negatively regulates GPR160 expression in lymphoblastoid cell lines
Species:  Human
Tissue:  Lymphoblastoid cell line
Response measured:  Decreased expression
References:  2
Clinically-Relevant Mutations and Pathophysiology
Disease:  Metastatic melanoma
Disease Ontology: DOID:4358
Comments: 
References:  4
Disease:  Nasopharyngeal carcinoma
OMIM: 607107
Comments: 
References:  3
Disease:  Prostate cancer
Disease Ontology: DOID:10283
OMIM: 176807
Comments: 
References:  1,3
Biologically Significant Variants
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  Q14E
Global MAF (%):  1
Subpopulation MAF (%):  AFR: 4
Minor allele count:  G=0.010/21
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 
Validation:  1000 Genomes, Frequency
Type:  Naturally occurring SNP
Species:  Human
Amino acid change:  V65I
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession: 

References

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1. Dijkman R, van Doorn R, Szuhai K, Willemze R, Vermeer MH, Tensen CP. (2007) Gene-expression profiling and array-based CGH classify CD4+CD56+ hematodermic neoplasm and cutaneous myelomonocytic leukemia as distinct disease entities. Blood, 109 (4): 1720-7. [PMID:17068154]

2. Lee JE, Hong EJ, Nam HY, Kim JW, Han BG, Jeon JP. (2011) MicroRNA signatures associated with immortalization of EBV-transformed lymphoblastoid cell lines and their clinical traits. Cell Prolif., 44 (1): 59-66. [PMID:21199010]

3. Mudipalli A, Owen RD, Preston RJ. (2005) The effect of arsenicals on ultraviolet-radiation-induced growth arrest and related signaling events in human keratinocytes. Int. J. Oncol., 27 (3): 769-78. [PMID:16077927]

4. Qin Y, Verdegaal EM, Siderius M, Bebelman JP, Smit MJ, Leurs R, Willemze R, Tensen CP, Osanto S. (2011) Quantitative expression profiling of G-protein-coupled receptors (GPCRs) in metastatic melanoma: the constitutively active orphan GPCR GPR18 as novel drug target. Pigment Cell Melanoma Res, 24 (1): 207-18. [PMID:20880198]

Contributors

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How to cite this page

Anthony P. Davenport, Stephen Alexander, Joanna L. Sharman, Adam J. Pawson, Helen E. Benson, Amy E. Monaghan, Wen Chiy Liew, Chido Mpamhanga, Jim Battey, Richard V. Benya, Robert T. Jensen, Sadashiva Karnik, Evi Kostenis, Eliot Spindel, Laura Storjohann, Kalyan Tirupula, Tom I. Bonner, Richard Neubig, Jean-Philippe Pin, Michael Spedding, Anthony Harmar.
Class A Orphans: GPR160. Last modified on 16/06/2015. Accessed on 17/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=140.