PLCγ1

Target id: 1407

Nomenclature: PLCγ1

Family: Phosphoinositide-specific phospholipase C

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     PLCγ1 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1291 20q12 PLCG1 phospholipase C gamma 1
Mouse - - Plcg1 phospholipase C, gamma 1
Rat - - Plcg1 phospholipase C, gamma 1
Previous and Unofficial Names
PLC1 | PLC148 | PLCgamma1 | phosphoinositide phospholipase C-gamma-1 | phospholipase C, gamma 1 | PPLCA | Cded | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | NCKAP3 | phospholipase C
Database Links
BRENDA
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Cofactors
Cofactor Species Comments Reference
Ca2+ Human
Endogenous activators (Human)
PIP3  [1]

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 5 [PMID: 10869194] Bt Inhibition 5.0 pIC50 3
pIC50 5.0 (IC50 9.5x10-6 M) [3]
Immunopharmacology Comments
Two structurally similar isoforms of PLCγ are expressed by mast cells (PLCγ1 and PLCγ2). Both are important enzymes in the integrated signalling pathways leading to mast cell activation [2,4], although PLCγ1 may be the predominant isoform active in human mast cells [5].
Cell Type Associations
Immuno Cell Type:  Mast cells
Cell Ontology Term:   mast cell (CL:0000097)
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 2 GO processes
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0050900 leukocyte migration TAS
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 1 GO processes
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 3 GO processes
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0050852 T cell receptor signaling pathway TAS
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes
GO:0050900 leukocyte migration TAS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 3 GO processes
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0050852 T cell receptor signaling pathway TAS

References

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1. Bae YS, Cantley LG, Chen CS, Kim SR, Kwon KS, Rhee SG. (1998) Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem., 273 (8): 4465-9. [PMID:9468499]

2. Gilfillan AM, Tkaczyk C. (2006) Integrated signalling pathways for mast-cell activation. Nat. Rev. Immunol., 6 (3): 218-30. [PMID:16470226]

3. Lee JS, Kim J, Kim BY, Lee HS, Ahn JS, Chang YS. (2000) Inhibition of phospholipase cgamma1 and cancer cell proliferation by triterpene esters from Uncaria rhynchophylla. J. Nat. Prod., 63 (6): 753-6. [PMID:10869194]

4. Saitoh S, Arudchandran R, Manetz TS, Zhang W, Sommers CL, Love PE, Rivera J, Samelson LE. (2000) LAT is essential for Fc(epsilon)RI-mediated mast cell activation. Immunity, 12 (5): 525-35. [PMID:10843385]

5. Tkaczyk C, Beaven MA, Brachman SM, Metcalfe DD, Gilfillan AM. (2003) The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase. J. Biol. Chem., 278 (48): 48474-84. [PMID:13129935]

How to cite this page

Phosphoinositide-specific phospholipase C: PLCγ1. Last modified on 14/02/2017. Accessed on 23/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1407.