PLCγ2

Target id: 1408

Nomenclature: PLCγ2

Family: Phosphoinositide-specific phospholipase C

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     PLCγ2 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 1265 16q24.1 PLCG2 phospholipase C gamma 2
Mouse - - Plcg2 phospholipase C, gamma 2
Rat - - Plcg2 phospholipase C, gamma 2
Previous and Unofficial Names
PLC-IV | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | phosphoinositide phospholipase C-gamma-2 | phospholipase C, gamma 2 | phospholipase C-IV | PLCgamma2 | phospholipase C, gamma 2 (phosphatidylinositol-specific) | phospholipase C
Database Links
BRENDA
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.1.4.11 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol
Cofactors
Cofactor Species Comments Reference
Ca2+ Human
Endogenous activators (Human)
PIP3, Rac1 (RAC1, P63000), Rac2 (RAC2, P15153), Rac3 (RAC3, P60763)  [1,3,7]

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
CCT129957 Hs Inhibition 5.5 pIC50 4
pIC50 5.5 (IC50 3x10-6 M) [4]
Description: Average IC50 (n=3)
Immunopharmacology Comments
Two structurally similar isoforms of PLCγ are expressed by mast cells (PLCγ1 and PLCγ2). Both are important enzymes in the integrated signalling pathways leading to mast cell activation [2,5], although PLCγ1 may be the predominant isoform active in human mast cells [6].
Cell Type Associations
Immuno Cell Type:  Mast cells
Cell Ontology Term:   mast cell (CL:0000097)
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 3 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
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GO:0002316 follicular B cell differentiation IEA
Immuno Process:  Antigen presentation
GO Annotations:  Associated to 2 GO processes
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
click arrow to show/hide IEA associations
GO:0002092 positive regulation of receptor internalization IEA
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 2 GO processes
GO:0030183 B cell differentiation ISS
click arrow to show/hide IEA associations
GO:0002316 follicular B cell differentiation IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 5 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0050852 T cell receptor signaling pathway ISS
GO:0050853 B cell receptor signaling pathway ISS
Immuno Process:  Immune system development
GO Annotations:  Associated to 2 GO processes
GO:0030183 B cell differentiation ISS
click arrow to show/hide IEA associations
GO:0002316 follicular B cell differentiation IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 7 GO processes
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0030183 B cell differentiation ISS
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0050852 T cell receptor signaling pathway ISS
GO:0050853 B cell receptor signaling pathway ISS
click arrow to show/hide IEA associations
GO:0002316 follicular B cell differentiation IEA
Immuno Process:  Cytokine production & signalling
GO Annotations:  Associated to 1 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0032481 positive regulation of type I interferon production IEA

References

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1. Bae YS, Cantley LG, Chen CS, Kim SR, Kwon KS, Rhee SG. (1998) Activation of phospholipase C-gamma by phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem., 273 (8): 4465-9. [PMID:9468499]

2. Gilfillan AM, Tkaczyk C. (2006) Integrated signalling pathways for mast-cell activation. Nat. Rev. Immunol., 6 (3): 218-30. [PMID:16470226]

3. Piechulek T, Rehlen T, Walliser C, Vatter P, Moepps B, Gierschik P. (2005) Isozyme-specific stimulation of phospholipase C-gamma2 by Rac GTPases. J. Biol. Chem., 280 (47): 38923-31. [PMID:16172125]

4. Reynisson J, Court W, O'Neill C, Day J, Patterson L, McDonald E, Workman P, Katan M, Eccles SA. (2009) The identification of novel PLC-gamma inhibitors using virtual high throughput screening. Bioorg. Med. Chem., 17 (8): 3169-76. [PMID:19303309]

5. Saitoh S, Arudchandran R, Manetz TS, Zhang W, Sommers CL, Love PE, Rivera J, Samelson LE. (2000) LAT is essential for Fc(epsilon)RI-mediated mast cell activation. Immunity, 12 (5): 525-35. [PMID:10843385]

6. Tkaczyk C, Beaven MA, Brachman SM, Metcalfe DD, Gilfillan AM. (2003) The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase. J. Biol. Chem., 278 (48): 48474-84. [PMID:13129935]

7. Walliser C, Retlich M, Harris R, Everett KL, Josephs MB, Vatter P, Esposito D, Driscoll PC, Katan M, Gierschik P et al.. (2008) rac regulates its effector phospholipase Cgamma2 through interaction with a split pleckstrin homology domain. J. Biol. Chem., 283 (44): 30351-62. [PMID:18728011]

How to cite this page

Phosphoinositide-specific phospholipase C: PLCγ2. Last modified on 14/02/2017. Accessed on 19/09/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1408.