<i>GPR161</i> | Class A Orphans | IUPHAR/BPS Guide to PHARMACOLOGY

GPR161

Target id: 141

Nomenclature: GPR161

Family: Class A Orphans

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for GPR161 in GtoImmuPdb

Gene and Protein Information
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 529 1q23.3 GPR161 G protein-coupled receptor 161
Mouse 7 558 1 H2.3 Gpr161 G protein-coupled receptor 161
Rat 7 577 13q23 Gpr161 G protein-coupled receptor 161
Previous and Unofficial Names
G-protein coupled receptor RE2
Database Links
Specialist databases
GPCRDB gp161_human (Hs), gp161_mouse (Mm)
Other databases
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Tissue Distribution
Mouse embryo. Expressed from E8.5 to E11.5. At E8.0-E9.5, expression was restricted to the lateral neural folds of the neural plate. Gpr161 is expressed at all examined stages of lens development: lens pit (E10.5), lens vesicle (E11.5), primary lens fiber cells (E12.5), and differentiating secondary lens fiber cells (E14.5). At E12.5 and E14.5, Gpr161 transcripts are restricted to differentiating lens fiber cells and are absent from the proliferating anterior lens epithelium. Gpr161 is also expressed in a number of other structures from E9.5 to E12.5, including the ventricular zone of the developing CNS (E9.5-E11.5), the fore and hindlimbs (E12.5), and the retina (E10.5-E14.5).
Species:  Mouse
Technique:  RT-PCR, In situ hybridization
References:  3
Expression Datasets

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Physiological Consequences of Altering Gene Expression Comments
GPR161 is required for right-left patterning in zebrafish development via modulation of Ca2+ in cells surrounding Kupffer's vesicles [2].
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Gpr161vl Gpr161vl/Gpr161vl
C3H/HeSn-Gpr161/J
MGI:2685054  MP:0001303 abnormal lens morphology
Gpr161vl Gpr161vl/Gpr161vl
C3H/HeSn-Gpr161/J
MGI:2685054  MP:0004837 abnormal neural fold formation PMID: 1731393 
Gpr161vl Gpr161vl/Gpr161vl
C3H/HeSn-Gpr161/J
MGI:2685054  MP:0000373 belly spot
Gpr161vl Gpr161vl/Gpr161vl
C3H/HeSn-Gpr161/J
MGI:2685054  MP:0001304 cataracts
Gpr161vl|Modvl3MOLF/EiJ Gpr161vl/Gpr161vl,Modvl3MOLF/EiJ/Modvl3MOLF/EiJ
involves: C3H/HeSnJ * MOLF/EiJ
MGI:2685054  MGI:3784974  MP:0001304 cataracts PMID: 18250320 
Gpr161vl|Modvl3C3H/HeSnJ|Modvl3MOLF/EiJ Gpr161vl/Gpr161vl,Modvl3C3H/HeSnJ/Modvl3MOLF/EiJ
involves: C3H/HeSnJ * MOLF/EiJ
MGI:2685054  MGI:3784974  MP:0001304 cataracts PMID: 18250320 
Gpr161vl Gpr161vl/Gpr161vl
involves: C3H/HeSnJ * C57BL/6J
MGI:2685054  MP:0000755 hindlimb paralysis PMID: 18250320 
Gpr161vl Gpr161vl/Gpr161vl
involves: C3H/HeSnJ * CAST/Ei
MGI:2685054  MP:0000755 hindlimb paralysis PMID: 18250320 
Gpr161vl Gpr161vl/Gpr161vl
C3H/HeSn-Gpr161/J
MGI:2685054  MP:0003054 spina bifida
Gpr161vl Gpr161vl/Gpr161vl
involves: C3H/HeSnJ * C57BL/6J
MGI:2685054  MP:0003054 spina bifida PMID: 18250320 
Gpr161vl Gpr161vl/Gpr161vl
involves: C3H/HeSnJ * CAST/Ei
MGI:2685054  MP:0003054 spina bifida PMID: 18250320 
Gpr161vl|Modvl1C3H/HeSnJ Gpr161vl/Gpr161vl,Modvl1C3H/HeSnJ/Modvl1C3H/HeSnJ
involves: C3H/HeSnJ * C57BL/6J
MGI:2685054  MGI:3784970  MP:0003054 spina bifida PMID: 18250320 
Gpr161vl|Modvl1C3H/HeSnJ|Modvl1C57BL/6J Gpr161vl/Gpr161vl,Modvl1C3H/HeSnJ/Modvl1C57BL/6J
involves: C3H/HeSnJ * C57BL/6J
MGI:2685054  MGI:3784970  MP:0003054 spina bifida PMID: 18250320 
Gpr161vl|Modvl2C3H/HeSnJ Gpr161vl/Gpr161vl,Modvl2C3H/HeSnJ/Modvl2C3H/HeSnJ
involves: C3H/HeSnJ * CAST/EiJ
MGI:2685054  MGI:3784972  MP:0003054 spina bifida PMID: 18250320 
Gpr161vl|Modvl2C3H/HeSnJ|Modvl2CAST/EiJ Gpr161vl/Gpr161vl,Modvl2C3H/HeSnJ/Modvl2CAST/EiJ
involves: C3H/HeSnJ * CAST/EiJ
MGI:2685054  MGI:3784972  MP:0003054 spina bifida PMID: 18250320 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Irritable bowel syndrome
Disease Ontology: DOID:9778
Comments: 
References:  4
Clinically-Relevant Mutations and Pathophysiology Comments
A C-terminal truncation (deletion) mutation in Gpr61 causes congenital cataracts and neural tube defects in the vacuolated lens (vl) mouse mutant. Foxe3 is a genetic modifier that interacts with GPR161 to regulate lens development [3]. The mutated receptor is associated with cataract, spina bifidia and white belly spot phenotypes in mice [1].
Biologically Significant Variant Comments
The vacuolated lens C-terminal GPR161 truncation mutation affects receptor mediated endocytosis [3].

References

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1. Korstanje R, Desai J, Lazar G, King B, Rollins J, Spurr M, Joseph J, Kadambi S, Li Y, Cherry A, Matteson PG, Paigen B, Millonig JH. (2008) Quantitative trait loci affecting phenotypic variation in the vacuolated lens mouse mutant, a multigenic mouse model of neural tube defects. Physiol. Genomics, 35 (3): 296-304. [PMID:18796533]

2. Leung T, Humbert JE, Stauffer AM, Giger KE, Chen H, Tsai HJ, Wang C, Mirshahi T, Robishaw JD. (2008) The orphan G protein-coupled receptor 161 is required for left-right patterning. Dev. Biol., 323 (1): 31-40. [PMID:18755178]

3. Matteson PG, Desai J, Korstanje R, Lazar G, Borsuk TE, Rollins J, Kadambi S, Joseph J, Rahman T, Wink J, Benayed R, Paigen B, Millonig JH. (2008) The orphan G protein-coupled receptor, Gpr161, encodes the vacuolated lens locus and controls neurulation and lens development. Proc. Natl. Acad. Sci. U.S.A., 105 (6): 2088-93. [PMID:18250320]

4. Swan C, Duroudier NP, Campbell E, Zaitoun A, Hastings M, Dukes GE, Cox J, Kelly FM, Wilde J, Lennon MG et al.. (2013) Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFα. Gut, 62 (7): 985-94. [PMID:22684480]

Contributors

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How to cite this page

Anthony P. Davenport, Stephen Alexander, Joanna L. Sharman, Adam J. Pawson, Helen E. Benson, Amy E. Monaghan, Wen Chiy Liew, Chido Mpamhanga, Jim Battey, Richard V. Benya, Robert T. Jensen, Sadashiva Karnik, Evi Kostenis, Eliot Spindel, Laura Storjohann, Kalyan Tirupula, Tom I. Bonner, Richard Neubig, Jean-Philippe Pin, Michael Spedding, Anthony Harmar.
Class A Orphans: GPR161. Last modified on 31/07/2015. Accessed on 13/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=141.