sPLA2-1B

Target id: 1416

Nomenclature: sPLA2-1B

Family: Phospholipase A2

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     sPLA2-1B has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - PLA2G1B phospholipase A2 group IB
Mouse - - Pla2g1b phospholipase A2, group IB, pancreas
Rat - - Pla2g1b phospholipase A2 group IB
Previous and Unofficial Names
GIB | pancreatic PLA2 | PLA2 | PLA2A | PPLA2 | group IB phospholipase A2 | phospholipase A2 group IB pancreas | sPLA2IB | phospholipase A2, group IB (pancreas) | phospholipase A2, group IB, pancreas
Database Links
BRENDA
CATH/Gene3D
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.1.1.4

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 28xvii [PMID: 8809154] Hs Inhibition 8.9 pIC50 1
pIC50 8.9 (IC50 1.3x10-9 M) [1]
Description: Measured using a chromogenic assay.
compound 12e [PMID: 18605714] Hs Inhibition 7.1 pIC50 3
pIC50 7.1 (IC50 8.4x10-8 M) [3]
Immunopharmacology Comments
sPLA2 enzymes catalyze the first step of the arachidonic acid pathway, so are inextricably involved in the production of arachadonic acid for inflammatory mediator synthesis. Excess sPLA2 activity is suggested to contribute to several inflammatory diseases. The sPLA2-1B isozyme has been reported to induce leukotriene B4 (LTB4) production in human neutrophils, using a mechanism independent of arachadonic acid generation [2].
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  innate immune response in mucosa (GO:0002227) IDA
neutrophil chemotaxis (GO:0030593) ISS
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of immune response (GO:0050778) ISS
References: 
Immuno Process:  Cytokine production & signalling
Immuno Process ID:  9
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  interleukin-8 production (GO:0032637) ISS
References: 
Immuno Process:  Chemotaxis & migration
Immuno Process ID:  10
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  neutrophil chemotaxis (GO:0030593) ISS
References: 

References

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1. Hagishita S, Yamada M, Shirahase K, Okada T, Murakami Y, Ito Y, Matsuura T, Wada M, Kato T, Ueno M et al.. (1996) Potent inhibitors of secretory phospholipase A2: synthesis and inhibitory activities of indolizine and indene derivatives. J. Med. Chem.39 (19): 3636-58. [PMID:8809154]

2. Lee HY, Kim MK, Park KS, Shin EH, Bae YS. (2005) Group IB secretory phospholipase A2 stimulates leukotriene B4 production by a unique mechanism in human neutrophils. Biochem. Biophys. Res. Commun.334 (2): 500-8. [PMID:16005851]

3. Oslund RC, Cermak N, Gelb MH. (2008) Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2. J. Med. Chem.51 (15): 4708-14. [PMID:18605714]

How to cite this page

Phospholipase A2: sPLA2-1B. Last modified on 16/02/2017. Accessed on 22/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1416.