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GPR162

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Target not currently curated in GtoImmuPdb

Target id: 142

Nomenclature: GPR162

Family: Class A Orphans

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 588 12p13 GPR162 G protein-coupled receptor 162
Mouse 7 588 6 59.17 cM Gpr162 G protein-coupled receptor 162
Rat 7 575 4q42 Gpr162 G protein-coupled receptor 162
Previous and Unofficial Names Click here for help
GRCA
Database Links Click here for help
Specialist databases
GPCRdb gp162_human (Hs), gp162_mouse (Mm)
Other databases
Alphafold Q16538 (Hs), Q3UN16 (Mm)
ChEMBL Target CHEMBL4523871 (Hs)
Ensembl Gene ENSG00000250510 (Hs), ENSMUSG00000038390 (Mm), ENSRNOG00000016143 (Rn)
Entrez Gene 27239 (Hs), 14788 (Mm), 362436 (Rn)
Human Protein Atlas ENSG00000250510 (Hs)
KEGG Gene hsa:27239 (Hs), mmu:14788 (Mm), rno:362436 (Rn)
Pharos Q16538 (Hs)
RefSeq Nucleotide NM_019858 (Hs), NM_013533 (Mm), NM_001108646 (Rn)
RefSeq Protein NP_062832 (Hs), NP_038561 (Mm), NP_001102116 (Rn)
UniProtKB Q16538 (Hs), Q3UN16 (Mm)
Wikipedia GPR162 (Hs)
Tissue Distribution Click here for help
Central nervous system, lung, sexual organs
Species:  Human
Technique:  Expressed sequence tag
References:  2
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants Click here for help
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  G450R
Global MAF (%):  3
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 6|2|3|3
Minor allele count:  A=0.032/70
Comment on frequency:  Low frequency (<10% in all tested populations)
SNP accession:  rs148895065
Validation:  Frequency
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  R459G
Global MAF (%):  15
Subpopulation MAF (%):  AFR|AMR|EUR: 1|23|30
Minor allele count:  G=0.146/319
SNP accession:  VAR_049407, rs11612427
Validation:  1000 Genomes, HapMap, Frequency
References:  1

References

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1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P et al.. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res, 14 (10B): 2121-7. [PMID:15489334]

2. Gloriam DE, Schiöth HB, Fredriksson R. (2005) Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. Biochim Biophys Acta, 1722 (3): 235-46. [PMID:15777626]

Contributors

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