cPLA2-4A

Target id: 1424

Nomenclature: cPLA2-4A

Family: Phospholipase A2

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for cPLA2-4A in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - PLA2G4A phospholipase A2 group IVA
Mouse - - Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent)
Rat - - Pla2g4a phospholipase A2 group IVA
Previous and Unofficial Names
Calcium-dependent PLA2 | cytosolic phospholipase A2 α | GIVA | phospholipase A2 group IVA | Pla2c | cPLA2-alpha | cytosolic PLA2 | phospholipase A2, group IVA (cytosolic, calcium-dependent)
Database Links
BRENDA
CATH/Gene3D
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.1.1.4

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 57 [PMID: 16610804] Hs Inhibition 8.4 pIC50 1
pIC50 8.4 (IC50 4.3x10-9 M) [1]
Description: Inhibition of human isolated cPLA2-4A in a lipid vesicle assay.

References

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1. Ludwig J, Bovens S, Brauch C, Elfringhoff AS, Lehr M. (2006) Design and synthesis of 1-indol-1-yl-propan-2-ones as inhibitors of human cytosolic phospholipase A2alpha. J. Med. Chem.49 (8): 2611-20. [PMID:16610804]

How to cite this page

Phospholipase A2: cPLA2-4A. Last modified on 16/09/2015. Accessed on 17/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1424.