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GPR171

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Target not currently curated in GtoImmuPdb

Target id: 143

Nomenclature: GPR171

Family: Class A Orphans

Contents:

Gene and Protein Information Click here for help
class A G protein-coupled receptor
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 7 319 3q25.1 GPR171 G protein-coupled receptor 171 2
Mouse 7 319 3 D Gpr171 G protein-coupled receptor 171
Rat 7 326 2q31 Gpr171 G protein-coupled receptor 171
Previous and Unofficial Names Click here for help
G-protein coupled receptor H963 | platelet activating receptor homolog
Database Links Click here for help
Specialist databases
GPCRdb gp171_human (Hs)
Other databases
Alphafold O14626 (Hs), Q8BG55 (Mm)
ChEMBL Target CHEMBL4523860 (Hs)
Ensembl Gene ENSG00000174946 (Hs), ENSMUSG00000050075 (Mm), ENSRNOG00000025297 (Rn)
Entrez Gene 29909 (Hs), 229323 (Mm), 688737 (Rn)
Human Protein Atlas ENSG00000174946 (Hs)
KEGG Gene hsa:29909 (Hs), mmu:229323 (Mm), rno:688737 (Rn)
Pharos O14626 (Hs)
RefSeq Nucleotide NM_013308 (Hs), NM_173398 (Mm), NM_001109510 (Rn)
RefSeq Protein NP_013308 (Hs), NP_775574 (Mm), NP_001102980 (Rn)
UniProtKB O14626 (Hs), Q8BG55 (Mm)
Wikipedia GPR171 (Hs)
Agonist Comments
GPR171 has been shown to be activated by endogenous peptide BigLEN. This receptor-peptide interaction is believed to be involved in regulating feeding and metabolism responses [1].
Immuno Process Associations
Immuno Process:  Immune regulation
Immuno Process:  Immune system development
Expression Datasets Click here for help

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Log average relative transcript abundance in mouse tissues measured by qPCR from Regard, J.B., Sato, I.T., and Coughlin, S.R. (2008). Anatomical profiling of G protein-coupled receptor expression. Cell, 135(3): 561-71. [PMID:18984166] [Raw data: website]

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Biologically Significant Variants Click here for help
Type:  Single nucleotide polymorphism
Species:  Human
Amino acid change:  I283V
Global MAF (%):  5
Subpopulation MAF (%):  AFR|AMR|ASN|EUR: 2|3|13|1
Minor allele count:  C=0.047/103
SNP accession:  rs3732756
Validation:  1000 Genomes, HapMap, Frequency
General Comments
GPR171 is excluded as a candidate gene of Usher syndrome Type 3 [3].

References

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1. Gomes I, Aryal DK, Wardman JH, Gupta A, Gagnidze K, Rodriguiz RM, Kumar S, Wetsel WC, Pintar JE, Fricker LD et al.. (2013) GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding. Proc Natl Acad Sci USA, 110 (40): 16211-6. [PMID:24043826]

2. Jacobs KA, Collins-Racie LA, Colbert M, Duckett M, Golden-Fleet M, Kelleher K, Kriz R, LaVallie ER, Merberg D, Spaulding V et al.. (1997) A genetic selection for isolating cDNAs encoding secreted proteins. Gene, 198 (1-2): 289-96. [PMID:9370294]

3. Joensuu T, Hämäläinen R, Yuan B, Johnson C, Tegelberg S, Gasparini P, Zelante L, Pirvola U, Pakarinen L, Lehesjoki AE et al.. (2001) Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3. Am J Hum Genet, 69 (4): 673-84. [PMID:11524702]

Contributors

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