PLA2-G7

Target id: 1432

Nomenclature: PLA2-G7

Family: Phospholipase A2, Hydrolases

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     PLA2-G7 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 441 6p21.2-p12 PLA2G7 phospholipase A2 group VII
Mouse - 440 17 C Pla2g7 phospholipase A2
Rat - 440 9q12 Pla2g7 phospholipase A2 group VII
Previous and Unofficial Names
GVII | platelet-activating factor acetylhydrolase | PAF acetylhydrolase | LDL-associated phospholipase A2 | LDL-PLA2 | PAFAH | phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
Database Links
BRENDA
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.1.1.4

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
darapladib Hs Inhibition 10.0 pIC50 1
pIC50 10.0 (IC50 1.1x10-10 M) [1]
rilapladib Hs Competitive 9.6 pIC50 3
pIC50 9.6 (IC50 2.3x10-10 M) [3]
Immunopharmacology Comments
Included in Guide to Immunopharmacology because of the association of PLA2G7 polymorphisms with atopy and asthma [2].
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of inflammatory response (GO:0050729) TAS
positive regulation of monocyte chemotaxis (GO:0090026) IDA
References: 
Immuno Process:  Immune regulation
Immuno Process ID:  6
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of inflammatory response (GO:0050729) TAS
positive regulation of monocyte chemotaxis (GO:0090026) IDA
References: 
Immuno Process:  Chemotaxis & migration
Immuno Process ID:  10
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  positive regulation of monocyte chemotaxis (GO:0090026) IDA
References: 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Asthma, susceptibility to
Disease Ontology: DOID:2841
OMIM: 600807
Disease:  IgE responsiveness, atopic; IGER
OMIM: 147050
Disease:  Platelet-activating factor acetylhydrolase deficiency
OMIM: 614278

References

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1. Blackie JA, Bloomer JC, Brown MJ, Cheng HY, Hammond B, Hickey DM, Ife RJ, Leach CA, Lewis VA, Macphee CH et al.. (2003) The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2. Bioorg. Med. Chem. Lett.13 (6): 1067-70. [PMID:12643913]

2. Kruse S, Mao XQ, Heinzmann A, Blattmann S, Roberts MH, Braun S, Gao PS, Forster J, Kuehr J, Hopkin JM et al.. (2000) The Ile198Thr and Ala379Val variants of plasmatic PAF-acetylhydrolase impair catalytical activities and are associated with atopy and asthma. Am. J. Hum. Genet.66 (5): 1522-30. [PMID:10733466]

3. Wilensky RL, Macphee CH. (2009) Lipoprotein-associated phospholipase A(2) and atherosclerosis. Curr. Opin. Lipidol.20 (5): 415-20. [PMID:19667981]

How to cite this page

Phospholipase A2: PLA2-G7. Last modified on 14/03/2017. Accessed on 14/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1432.