PLD2

Target id: 1434

Nomenclature: PLD2

Family: Hydrolases, Phosphatidylcholine-specific phospholipase D

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for PLD2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 933 17p13.3 PLD2 phospholipase D2
Mouse - 933 11 B3 Pld2 phospholipase D2
Rat - 933 10q23.3-q24 Pld2 phospholipase D2
Previous and Unofficial Names
Choline phosphatase 2 | phosphatidylcholine-hydrolyzing phospholipase D2 | phospholipase D2 | PLD1C
Database Links
BRENDA
CATH/Gene3D
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.1.4.4
Description Reaction Reference
A phosphatidylcholine + H2O <=> choline + a phosphatidate
Endogenous inhibitor (Human)
Gβγ  [3]

Download all structure-activity data for this target as a CSV file

Activators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
oleic acid Hs Activation - - 4
[4]
PIP2 Hs Activation - - 2
[2]
ADP-ribosylation factor 1 {Sp: Human} Hs Activation - -
Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
FIPI Hs Inhibition 7.8 pIC50 5
pIC50 7.8 (IC50 1.7x10-8 M) [5]
VU0364739 Hs Inhibition 7.7 pIC50 1
pIC50 7.7 (IC50 1.99x10-8 M) [1]
compound 69 [PMID: 19136975] Hs Inhibition 6.0 pIC50 5
pIC50 6.0 (IC50 9.33x10-7 M) [5]

References

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1. Lavieri RR, Scott SA, Selvy PE, Kim K, Jadhav S, Morrison RD, Daniels JS, Brown HA, Lindsley CW. (2010) Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor. J. Med. Chem.53 (18): 6706-19. [PMID:20735042]

2. Lopez I, Arnold RS, Lambeth JD. (1998) Cloning and initial characterization of a human phospholipase D2 (hPLD2). ADP-ribosylation factor regulates hPLD2. J. Biol. Chem.273 (21): 12846-52. [PMID:9582313]

3. Preininger AM, Henage LG, Oldham WM, Yoon EJ, Hamm HE, Brown HA. (2006) Direct modulation of phospholipase D activity by Gbetagamma. Mol. Pharmacol.70 (1): 311-8. [PMID:16638972]

4. Sarri E, Pardo R, Fensome-Green A, Cockcroft S. (2003) Endogenous phospholipase D2 localizes to the plasma membrane of RBL-2H3 mast cells and can be distinguished from ADP ribosylation factor-stimulated phospholipase D1 activity by its specific sensitivity to oleic acid. Biochem. J.369 (Pt 2): 319-29. [PMID:12374567]

5. Scott SA, Selvy PE, Buck JR, Cho HP, Criswell TL, Thomas AL, Armstrong MD, Arteaga CL, Lindsley CW, Brown HA. (2009) Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat. Chem. Biol.5 (2): 108-17. [PMID:19136975]

How to cite this page

Phosphatidylcholine-specific phospholipase D: PLD2. Last modified on 16/09/2015. Accessed on 21/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1434.