IP3 kinase B

Target id: 1448

Nomenclature: IP3 kinase B

Family: Inositol 1,4,5-trisphosphate 3-kinases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     IP3 kinase B has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - - ITPKB inositol-trisphosphate 3-kinase B
Mouse - - Itpkb inositol 1,4,5-trisphosphate 3-kinase B
Rat - - Itpkb inositol-trisphosphate 3-kinase B
Previous and Unofficial Names
IP3-3KB | IP3KB | inositol 1,4,5-trisphosphate 3-kinase B | insP 3-kinase B | inositol 1
Database Links
BRENDA
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.1.127

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
GNF362 Hs Inhibition 8.1 pIC50 1
pIC50 8.1 (IC50 9x10-9 M) [1]
Immunopharmacology Comments
IP3 kinase B (ITPKB) as an essential mediator of T cell activation, whose inhibition is considered a novel approach to treat autoimmune disease [1]. ITPKB inhibition blocks T-cell dependent antibody responses in vivo. GNF362 is a non-selective inhibitor of all three of the IP3 kinases in the family to which ITPKB belongs.
Immuno Process Associations
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 2 GO processes, IEA only
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GO:0045059 positive thymic T cell selection IEA
GO:0046638 positive regulation of alpha-beta T cell differentiation IEA
Immuno Process:  Immune regulation
GO Annotations:  Associated to 4 GO processes, IEA only
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GO:0002262 myeloid cell homeostasis IEA
GO:0033030 negative regulation of neutrophil apoptotic process IEA
GO:0045638 negative regulation of myeloid cell differentiation IEA
GO:0046638 positive regulation of alpha-beta T cell differentiation IEA
Immuno Process:  Immune system development
GO Annotations:  Associated to 3 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0045059 positive thymic T cell selection IEA
GO:0045638 negative regulation of myeloid cell differentiation IEA
GO:0046638 positive regulation of alpha-beta T cell differentiation IEA
Immuno Process:  Chemotaxis & migration
GO Annotations:  Associated to 1 GO processes, IEA only
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GO:0046638 positive regulation of alpha-beta T cell differentiation IEA
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 2 GO processes, IEA only
click arrow to show/hide IEA associations
GO:0045059 positive thymic T cell selection IEA
GO:0046638 positive regulation of alpha-beta T cell differentiation IEA

References

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1. Miller AT, Dahlberg C, Sandberg ML, Wen BG, Beisner DR, Hoerter JA, Parker A, Schmedt C, Stinson M, Avis J et al.. (2015) Inhibition of the Inositol Kinase Itpkb Augments Calcium Signaling in Lymphocytes and Reveals a Novel Strategy to Treat Autoimmune Disease. PLoS ONE10 (6): e0131071. [PMID:26121493]

How to cite this page

Inositol 1,4,5-trisphosphate 3-kinases: IP3 kinase B. Last modified on 20/04/2017. Accessed on 23/04/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1448.