IMPase 1

Target id: 1463

Nomenclature: IMPase 1

Family: Inositol monophosphatase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for IMPase 1 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 277 8q21.1-q21.3 IMPA1 inositol monophosphatase 1
Mouse - 277 3 2.61 cM Impa1 inositol (myo)-1(or 4)-monophosphatase 1
Rat - 277 2q23 Impa1 inositol monophosphatase 1
Previous and Unofficial Names
IMP 1 | lithium-sensitive myo-inositol monophosphatase A1 | inositol(myo)-1(or 4)-monophosphatase 1 | Inositol (myo)-1(or 4)-monophosphatase 1
Database Links
BRENDA
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.1.3.25
Rank order of affinity (Human)
inositol 4-phosphate > inositol 3-phosphate > inositol 1-phosphate  [1]

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Inhibitors
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
Li+ Hs Inhibition 3.5 pKi 1
pKi 3.5 [1]
Inhibitor Comments
Lithium is administered as salts such as lithium carbonate and lithium nitrate.

References

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1. McAllister G, Whiting P, Hammond EA, Knowles MR, Atack JR, Bailey FJ, Maigetter R, Ragan CI. (1992) cDNA cloning of human and rat brain myo-inositol monophosphatase. Expression and characterization of the human recombinant enzyme. Biochem. J.284 ( Pt 3): 749-54. [PMID:1377913]

How to cite this page

Inositol monophosphatase: IMPase 1. Last modified on 26/03/2014. Accessed on 15/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1463.