protein kinase, cAMP-dependent, catalytic, gamma subunit | Protein kinase A (PKA) family | IUPHAR/BPS Guide to PHARMACOLOGY

protein kinase, cAMP-dependent, catalytic, gamma subunit

Target id: 1478

Nomenclature: protein kinase, cAMP-dependent, catalytic, gamma subunit

Abbreviated Name: PKACg

Family: Protein kinase A (PKA) family

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for protein kinase, cAMP-dependent, catalytic, gamma subunit in GtoImmuPdb

Quaternary Structure: Complexes
protein kinase A
Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 351 9q13 PRKACG protein kinase cAMP-activated catalytic subunit gamma
Previous and Unofficial Names
protein kinase, cAMP-dependent, gamma catalytic subunit
Database Links
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.11
EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: ...1

Key to terms and symbols Click column headers to sort
Target used in screen: nd/PKAcg
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
staurosporine Hs Inhibitor Inhibition 3.0
K-252a Hs Inhibitor Inhibition 10.8
SB 218078 Hs Inhibitor Inhibition 39.8
PP1 analog II Hs Inhibitor Inhibition 55.2
midostaurin Hs Inhibitor Inhibition 58.1
SB202190 Hs Inhibitor Inhibition 78.4
LY 303511 Hs Inhibitor Inhibition 83.2
VEGF receptor tyrosine kinase inhibitor II Hs Inhibitor Inhibition 87.4
AG 1296 Hs Inhibitor Inhibition 87.6
semaxanib Hs Inhibitor Inhibition 87.6
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1039-45. [PMID:22037377]

How to cite this page

Protein kinase A (PKA) family: protein kinase, cAMP-dependent, catalytic, gamma subunit. Last modified on 20/03/2013. Accessed on 14/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1478.