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Serine/threonine kinase 38 like

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Target not currently curated in GtoImmuPdb

Target id: 1518

Nomenclature: Serine/threonine kinase 38 like

Abbreviated Name: NDR2

Family: NDR family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 464 12p11.23 STK38L serine/threonine kinase 38 like
Mouse - 464 6 G3 Stk38l serine/threonine kinase 38 like
Rat - 464 4q44 Stk38l serine/threonine kinase 38 like
Previous and Unofficial Names Click here for help
nuclear Dbf2-related kinase 2
Database Links Click here for help
Alphafold Q9Y2H1 (Hs), Q7TSE6 (Mm)
BRENDA 2.7.11.1
ChEMBL Target CHEMBL4851 (Hs)
Ensembl Gene ENSG00000211455 (Hs), ENSMUSG00000001630 (Mm), ENSRNOG00000001828 (Rn)
Entrez Gene 23012 (Hs), 232533 (Mm)
Human Protein Atlas ENSG00000211455 (Hs)
KEGG Enzyme 2.7.11.1
KEGG Gene hsa:23012 (Hs), mmu:232533 (Mm)
Pharos Q9Y2H1 (Hs)
RefSeq Nucleotide NM_015000 (Hs), NM_172734 (Mm), NM_001083336 (Rn)
RefSeq Protein NP_055815 (Hs), NP_766322 (Mm), NP_001076805 (Rn)
UniProtKB Q9Y2H1 (Hs), Q7TSE6 (Mm)
Wikipedia STK38L (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.1

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 27 [PMID: 21123062] Small molecule or natural product Click here for species-specific activity table Hs Inhibition - - 2
⤷ [2]
Description: Measured as % inhibition using 1μM compound.
Inhibitor Comments
STK38L is inhibited by 99% in the presence of 1μM compound 27 [PMID 21123062] [2].
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1,3
Key to terms and symbols Click column headers to sort
Target used in screen: NDR2
Ligand Sp. Type Action Value Parameter
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.6 pKd
lestaurtinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition 6.4 pKd
NVP-TAE684 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 6.2 pKd
sunitinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition 6.0 pKd
KW-2449 Small molecule or natural product Hs Inhibitor Inhibition 6.0 pKd
SU-14813 Small molecule or natural product Hs Inhibitor Inhibition 5.7 pKd
AST-487 Small molecule or natural product Hs Inhibitor Inhibition 5.7 pKd
SB203580 Small molecule or natural product Immunopharmacology Ligand Hs Inhibitor Inhibition <5.5 pKd
ruboxistaurin Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition <5.5 pKd
erlotinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Weinberg LR, Albom MS, Angeles TS, Husten J, Lisko JG, McHugh RJ, Milkiewicz KL, Murthy S, Ott GR, Theroff JP et al.. (2011) Fused bicyclic derivatives of 2,4-diaminopyrimidine as c-Met inhibitors. Bioorg Med Chem Lett, 21 (1): 164-7. [PMID:21123062]

3. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

NDR family: Serine/threonine kinase 38 like. Last modified on 24/02/2015. Accessed on 18/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1518.