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serine/threonine kinase 32B

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Target not currently curated in GtoImmuPdb

Target id: 1538

Nomenclature: serine/threonine kinase 32B

Abbreviated Name: YANK2

Family: YANK family

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 414 4p16.2 STK32B serine/threonine kinase 32B
Mouse - 414 5 B3 Stk32b serine/threonine kinase 32B
Rat - 414 14q21 Stk32b serine/threonine kinase 32B
Previous and Unofficial Names Click here for help
STK32 | STKG6
Database Links Click here for help
Alphafold Q9NY57 (Hs), Q9JJX8 (Mm)
BRENDA 2.7.11.1
ChEMBL Target CHEMBL5912 (Hs)
Ensembl Gene ENSG00000152953 (Hs), ENSMUSG00000029123 (Mm), ENSRNOG00000031397 (Rn)
Entrez Gene 55351 (Hs), 64293 (Mm), 305431 (Rn)
Human Protein Atlas ENSG00000152953 (Hs)
KEGG Enzyme 2.7.11.1
KEGG Gene hsa:55351 (Hs), mmu:64293 (Mm), rno:305431 (Rn)
Pharos Q9NY57 (Hs)
RefSeq Nucleotide NM_018401 (Hs), NM_022416 (Mm), NM_001107224 (Rn)
RefSeq Protein NP_060871 (Hs), NP_071861 (Mm), NP_001100694 (Rn)
UniProtKB Q9NY57 (Hs), Q9JJX8 (Mm)
Wikipedia STK32B (Hs)
Enzyme Reaction Click here for help
EC Number: 2.7.11.1

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 74 [PMID: 24793884] Small molecule or natural product Click here for species-specific activity table Hs Inhibition - - 2
⤷ [2]
Description: Measured as % inhibition using 1μM compound.
Inhibitor Comments
STK32B activity is completely abolished in the presence of 1μM compound 74 [PMID 24793884] [2] (note that STK32B is referred to by its synonym YANK2 in the article's Supplementary data table)..
DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1,3
Key to terms and symbols Click column headers to sort
Target used in screen: YANK2
Ligand Sp. Type Action Value Parameter
NVP-TAE684 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.6 pKd
staurosporine Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 7.0 pKd
linifanib Small molecule or natural product Hs Inhibitor Inhibition 6.6 pKd
PD-173955 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 5.9 pKd
PP-242 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition 5.8 pKd
SB203580 Small molecule or natural product Immunopharmacology Ligand Hs Inhibitor Inhibition 5.7 pKd
ruboxistaurin Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition <5.5 pKd
erlotinib Small molecule or natural product Approved drug Ligand has a PDB structure Hs Inhibitor Inhibition <5.5 pKd
GSK690693 Small molecule or natural product Ligand has a PDB structure Hs Inhibitor Inhibition <5.5 pKd
masitinib Small molecule or natural product Ligand has a PDB structure Immunopharmacology Ligand Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat Biotechnol, 29 (11): 1046-51. [PMID:22037378]

2. Reichelt A, Bailis JM, Bartberger MD, Yao G, Shu H, Kaller MR, Allen JG, Weidner MF, Keegan KS, Dao JH. (2014) Synthesis and structure-activity relationship of trisubstituted thiazoles as Cdc7 kinase inhibitors. Eur J Med Chem, 80: 364-82. [PMID:24793884]

3. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem Biol, 17 (11): 1241-9. [PMID:21095574]

How to cite this page

YANK family: serine/threonine kinase 32B. Last modified on 25/02/2015. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1538.