X-prolyl aminopeptidase 2

Target id: 1579

Nomenclature: X-prolyl aminopeptidase 2

Family: M24: Methionyl aminopeptidase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for X-prolyl aminopeptidase 2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 674 Xq25 XPNPEP2 X-prolyl aminopeptidase 2
Mouse - 674 X A3.2 Xpnpep2 X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound
Rat - 674 Xq35 Xpnpep2 X-prolyl aminopeptidase 2
Previous and Unofficial Names
Aminopeptidase P 2 | membrane-bound X-prolyl aminopeptidase | mAPP | X-prolyl aminopeptidase (aminopeptidase P) 2
Database Links
Specialist databases
MEROPS M24.005 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.11.9

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
apstatin Hs Inhibition 6.2 pKi 1
pKi 6.2 (Ki 6.4x10-7 M) [1]
compound 6 [PMID: 10395480] Hs Inhibition 6.6 pIC50 1
pIC50 6.6 (IC50 2.3x10-7 M) [1]
apstatin Hs Inhibition 5.5 pIC50 1
pIC50 5.5 (IC50 2.9x10-6 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Angioedema induced by ACE inhibitors, susceptibility to; AEACEI
Synonyms: Renin-angiotensin-aldosterone system-blocker-induced angioedema [Orphanet: ORPHA100057]
OMIM: 300909
Orphanet: ORPHA100057

References

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1. Maggiora LL, Orawski AT, Simmons WH. (1999) Apstatin analogue inhibitors of aminopeptidase P, a bradykinin-degrading enzyme. J. Med. Chem.42 (13): 2394-402. [PMID:10395480]

How to cite this page

M24: Methionyl aminopeptidase: X-prolyl aminopeptidase 2. Last modified on 18/09/2015. Accessed on 23/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1579.