Cathepsin A

Target id: 1581

Nomenclature: Cathepsin A

Family: S10: Carboxypeptidase Y

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 480 20q13.12 CTSA cathepsin A
Mouse - 474 2 H3 Ctsa cathepsin A
Rat - 456 3q42 Ctsa cathepsin A
Previous and Unofficial Names
carboxypeptidase C
GSL
PPGB
carboxypeptidase Y-like kininase
carboxypeptidase-L
deamidase
lysosomal carboxypeptidase A
lysosomal protective protein
urinary kininase
protective protein for beta-galactosidase
PPCA
Database Links
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
ExplorEnz
GeneCards
GenitoUrinary Development Molecular Anatomy Project
Human Protein Reference Database
InterPro
KEGG BRITE Hierarchy
KEGG Gene
MEROPS
OMIM
Orphanet Gene
PhosphoSitePlus
RefSeq Nucleotide
RefSeq Protein
TreeFam
UniGene Hs.
UniProtKB
Enzyme Reaction
EC Number: 3.4.16.5
Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
Compound 8a (PMID 22861813) Hs Inhibition 7.42 pIC50 4
pIC50 7.42 (IC50 3.8x10-8 M) [4]
Example 166 (WO2014154727) Hs Inhibition 7.04 pIC50 3
pIC50 7.04 (IC50 9.2x10-8 M) [3]
telaprevir Hs Inhibition 7.0 pIC50 2
pIC50 7.0 (IC50 1x10-7 M) [2]
boceprevir Hs Inhibition 6.0 pIC50 1
pIC50 6.0 (IC50 1x10-6 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Galactosialidosis
OMIM:  256540
Orphanet:  351

References

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1. Ruf S et al.. (2013) Use of boceprevir and related compounds in atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases. Patent number: WO2013072327. Assignee: Sanofi. Priority date: 14/11/2011. Publication date: 23/05/2013.

2. Ruf S et al. (2013) Use of telaprevir and related compounds in atherosclerosis, heart failure, renal diseases, liver diseases or inflammatory diseases. Patent number: WO2013072328. Assignee: Sanofi. Priority date: 14/11/2011. Publication date: 23/05/2013.

3. Ruf S et al. (2014) Biaryl-propionic acid derivatives and their use as pharmaceuticals. Patent number: WO2014154727. Assignee: Sanofi. Priority date: 20/03/2013. Publication date: 02/10/2014.

4. Ruf S, Buning C, Schreuder H, Horstick G, Linz W, Olpp T, Pernerstorfer J, Hiss K, Kroll K, Kannt A et al.. (2012) Novel β-amino acid derivatives as inhibitors of cathepsin A. J. Med. Chem.55 (17): 7636-49. [PMID:22861813]

How to cite this page

S10: Carboxypeptidase Y: Cathepsin A. Last modified on 05/11/2014. Accessed on 22/12/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1581.