Prolylcarboxypeptidase

Target id: 1584

Nomenclature: Prolylcarboxypeptidase

Family: S28: Lysosomal Pro-Xaa carboxypeptidase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Prolylcarboxypeptidase in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 496 11q14 PRCP prolylcarboxypeptidase
Mouse - 491 7 E2 Prcp prolylcarboxypeptidase (angiotensinase C)
Rat - 493 1q32 Prcp prolylcarboxypeptidase
Previous and Unofficial Names
Angiotensinase C | HUMPCP | lysosomal Pro-X carboxypeptidase | PCP | prolylcarboxypeptidase (angiotensinase C)
Database Links
Specialist databases
MEROPS S28.001 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.16.2

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 35 [PMID: 24157366] Hs Inhibition 10.1 pIC50 1
pIC50 10.1 (IC50 7.9x10-11 M) [1]

References

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1. Debenham JS, Graham TH, Verras A, Zhang Y, Clements MJ, Kuethe JT, Madsen-Duggan C, Liu W, Bhatt UR, Chen D et al.. (2013) Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors. Bioorg. Med. Chem. Lett.23 (23): 6228-33. [PMID:24157366]

How to cite this page

S28: Lysosomal Pro-Xaa carboxypeptidase: Prolylcarboxypeptidase. Last modified on 14/07/2015. Accessed on 23/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1584.