Carboxypeptidase B1 (tissue)

Target id: 1593

Nomenclature: Carboxypeptidase B1 (tissue)

Family: M14: Carboxypeptidase A

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Carboxypeptidase B1 (tissue) in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 417 3q24 CPB1 carboxypeptidase B1
Mouse - 415 3 A2 Cpb1 carboxypeptidase B1 (tissue)
Rat - 415 2q24 Cpb1 carboxypeptidase B1
Previous and Unofficial Names
protaminase | tissue carboxypeptidase B | Cpb | pancreatic carboxypeptidase B1 | carboxypeptidase B1 (tissue)
Database Links
Specialist databases
MEROPS M14.003 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.17.2

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 4 [PMID: 19954973] Hs Inhibition 7.6 pKi 2
pKi 7.6 (Ki 2.7x10-8 M) [2]
compound 3 [PMID: 14640538] Hs Inhibition 8.1 pIC50 1
pIC50 8.1 (IC50 8.2x10-9 M) [1]

References

Show »

1. Barrow JC, Nantermet PG, Stauffer SR, Ngo PL, Steinbeiser MA, Mao SS, Carroll SS, Bailey C, Colussi D, Bosserman M et al.. (2003) Synthesis and evaluation of imidazole acetic acid inhibitors of activated thrombin-activatable fibrinolysis inhibitor as novel antithrombotics. J. Med. Chem.46 (25): 5294-7. [PMID:14640538]

2. Owen DR, Bull DJ, Bunnage ME, Glossop MS, Maguire RJ, Strang RS. (2010) Oxygenated analogues of UK-396082 as inhibitors of activated thrombin activatable fibrinolysis inhibitor. Bioorg. Med. Chem. Lett.20 (1): 92-6. [PMID:19954973]

How to cite this page

M14: Carboxypeptidase A: Carboxypeptidase B1 (tissue). Last modified on 29/07/2015. Accessed on 23/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1593.