Angiotensin-converting enzyme 2

Target id: 1614

Nomenclature: Angiotensin-converting enzyme 2

Abbreviated Name: ACE2

Family: M2: Angiotensin-converting (ACE and ACE2)

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Angiotensin-converting enzyme 2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human 1 788 Xp22 ACE2 angiotensin I converting enzyme 2
Mouse 1 788 X 76.12 cM Ace2 angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
Rat 1 788 Xq21 Ace2 angiotensin I converting enzyme 2
Previous and Unofficial Names
ACE-related carboxypeptidase | renal angiotensin-converting enzyme 2 | angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
Database Links
Specialist databases
MEROPS M02.006 (Hs)
Other databases
BRENDA
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
SynPHARM
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.15.1
Endogenous substrates (Human)
angiotensin I (AGT, P01019) > angiotensin-(1-9) (AGT, P01019)  [1]

Download all structure-activity data for this target as a CSV file

Activators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
XNT [PMID: 18391097] Hs Activation 4.7 pEC50 2
pEC50 4.7 (EC50 2.01x10-5 M) [2]
Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 28 [PMID: 18324760] Hs Inhibition 9.9 pKi 3
pKi 9.9 (Ki 1.3x10-10 M) [3]
MLN-4760 Hs Inhibition 9.4 pIC50 3
pIC50 9.4 (IC50 4.4x10-10 M) [3]
Other Binding Ligands
Key to terms and symbols Click column headers to sort
Ligand Sp. Action Affinity Units Reference
Abz-Ser-Pro-Tyr(NO2)-OH Hs Binding - - 4
[4]

References

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1. Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R et al.. (2000) A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ. Res.87 (5): E1-9. [PMID:10969042]

2. Hernández Prada JA, Ferreira AJ, Katovich MJ, Shenoy V, Qi Y, Santos RA, Castellano RK, Lampkins AJ, Gubala V, Ostrov DA et al.. (2008) Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents. Hypertension51 (5): 1312-7. [PMID:18391097]

3. Mores A, Matziari M, Beau F, Cuniasse P, Yiotakis A, Dive V. (2008) Development of potent and selective phosphinic peptide inhibitors of angiotensin-converting enzyme 2. J. Med. Chem.51 (7): 2216-26. [PMID:18324760]

4. Yan ZH, Ren KJ, Wang Y, Chen S, Brock TA, Rege AA. (2003) Development of intramolecularly quenched fluorescent peptides as substrates of angiotensin-converting enzyme 2. Anal. Biochem.312 (2): 141-7. [PMID:12531198]

How to cite this page

M2: Angiotensin-converting (ACE and ACE2): Angiotensin-converting enzyme 2. Last modified on 04/04/2016. Accessed on 19/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1614.