Caspase 7

Target id: 1623

Nomenclature: Caspase 7

Family: C14: Caspase

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Caspase 7 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 303 10q25 CASP7 caspase 7
Mouse - 303 19 D2 Casp7 caspase 7
Rat - 303 1q55 Casp7 caspase 7
Previous and Unofficial Names
apoptotic protease Mch-3 | CMH-1 | ICE-LAP3 | ICE-like apoptotic protease 3 | ICE-IAP3 | MCH3 | caspase 7, apoptosis-related cysteine peptidase
Database Links
Specialist databases
MEROPS C14.004 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.22.60
Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
huntingtin Hs - -
retinoblastoma-associated protein Hs - -
caspase 3 Hs - -
ICAD Hs - -
PARP Hs - -
PKCδ Hs - -
Pro-caspase 7 Hs - -
Endogenous activators (Human)
Caspase 8, caspase 9, caspase 10, GrB

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
isatin sulfonamide 34 [PMID: 11384246] Hs Inhibition 8.2 pKi 3
pKi 8.2 (Ki 6x10-9 M) [3]
compound 4 [PMID: 12408711] Hs Inhibition 6.9 pKi 1
pKi 6.9 (Ki 1.3x10-7 M) [1]
M826 Hs Inhibition 7.9 pIC50 2
pIC50 7.9 (IC50 1.3x10-8 M) [2]

References

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1. Choong IC, Lew W, Lee D, Pham P, Burdett MT, Lam JW, Wiesmann C, Luong TN, Fahr B, DeLano WL et al.. (2002) Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design. J. Med. Chem.45 (23): 5005-22. [PMID:12408711]

2. Han Y, Giroux A, Colucci J, Bayly CI, Mckay DJ, Roy S, Xanthoudakis S, Vaillancourt J, Rasper DM, Tam J et al.. (2005) Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors. Bioorg. Med. Chem. Lett.15 (4): 1173-80. [PMID:15686936]

3. Lee D, Long SA, Murray JH, Adams JL, Nuttall ME, Nadeau DP, Kikly K, Winkler JD, Sung CM, Ryan MD et al.. (2001) Potent and selective nonpeptide inhibitors of caspases 3 and 7. J. Med. Chem.44 (12): 2015-26. [PMID:11384246]

How to cite this page

C14: Caspase: Caspase 7. Last modified on 27/07/2015. Accessed on 22/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1623.