Caspase 10

Target id: 1626

Nomenclature: Caspase 10

Family: C14: Caspase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for Caspase 10 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 521 2q33-q34 CASP10 caspase 10
Previous and Unofficial Names
apoptotic protease Mch-4 | FLICE2 | ICE-like apoptotic protease 4 | FAS-associated death domain protein interleukin-1B-converting enzyme 2 | MCH4 | caspase 10, apoptosis-related cysteine peptidase
Database Links
Specialist databases
MEROPS C14.011 (Hs)
Other databases
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.22.63
Substrates and Reaction Kinetics
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
caspase 10 Hs - -
pro-caspase 3 Hs - -
pro-caspase 6 Hs - -
pro-caspase 7 Hs - -
Endogenous activators (Human)
DISC
Clinically-Relevant Mutations and Pathophysiology
Disease:  Autoimmune lymphoproliferative syndrome, type IIA; ALPS2A
Synonyms: Autoimmune lymphoproliferative syndrome [Orphanet: ORPHA3261] [Disease Ontology: DOID:6688]
Disease Ontology: DOID:6688
OMIM: 603909
Orphanet: ORPHA3261
Disease:  Gastric cancer
Synonyms: Stomach cancer
Disease Ontology: DOID:10534
OMIM: 613659
Disease:  Lymphoma, non-hodgkin, familial
Description: A lymphoma that is characterized as any kind of lymphoma except Hodgkin's lymphoma. Symptoms include enlarged lymph nodes, fever, night sweats, weight loss, and lethargy.
Synonyms: Non-Hodgkin lymphoma [Disease Ontology: DOID:0060060]
Disease Ontology: DOID:0060060
OMIM: 605027

How to cite this page

C14: Caspase: Caspase 10. Last modified on 26/01/2015. Accessed on 17/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1626.