MMP1

Target id: 1628

Nomenclature: MMP1

Family: M10: Matrix metallopeptidase

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

This target is also described as a ligand entry: matrix metalloproteinase 1

   GtoImmuPdb view: OFF :     MMP1 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 469 11q21-q22 MMP1 matrix metallopeptidase 1
Mouse - 464 9 A1-A2 Mmp1a matrix metallopeptidase 1a (interstitial collagenase)
Rat - 464 8q11 Mmp1 matrix metallopeptidase 1
Previous and Unofficial Names
Collagenase-1 | fibroblast collagenase | matrix metallopeptidase 1a | Mcol-A | CLG | matrix metallopeptidase 1 (interstitial collagenase)
Database Links
Specialist databases
MEROPS M10.001 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.24.7

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
cipemastat Hs Inhibition 8.5 pKi 1
pKi 8.5 (Ki 3x10-9 M) [1]
ilomastat Hs Inhibition 8.2 pIC50 3
pIC50 8.2 (IC50 6x10-9 M) [3]
CGS-27023A Hs Inhibition 7.3 pIC50 4
pIC50 7.3 (IC50 5.6x10-8 M) [4]
Immunopharmacology Comments
Overexpression of MMP-1 degrades extracellular matrix causing damage to the colon mucosa in patients with ulcerative colitis. The MMP-1 promotes secretion of TNFα causing futher damage. Levels of MMP-1 and TNFα correlate with disease severity [5].
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process ID:  2
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  leukocyte migration (GO:0050900) TAS
References: 
Immuno Process:  Chemotaxis & migration
Immuno Process ID:  10
Comment: 
GO Annotation:  Associated to GO processes
GO Processes:  leukocyte migration (GO:0050900) TAS
References: 
Immuno Disease Associations
Disease Name:  Rheumatoid arthritis
Disease Synonyms:  no synonynms
Comment:  Serum level of MMP1 correlates with disease activity in RA.
Disease X-refs:  Disease Ontology: DOID:7148
OMIM: 180300
References:  2
Clinically-Relevant Mutations and Pathophysiology
Disease:  Epidermolysis bullosa dystrophica, autosomal recessive
Synonyms: Epidermolysis bullosa dystrophica [Disease Ontology: DOID:4959]
Severe generalized recessive dystrophic epidermolysis bullosa [Orphanet: ORPHA79408]
Disease Ontology: DOID:4959
OMIM: 226600
Orphanet: ORPHA79408

References

Show »

1. Close DR. (2001) Matrix metalloproteinase inhibitors in rheumatic diseases. Ann. Rheum. Dis.60 Suppl 3: iii62-7. [PMID:11890658]

2. Green MJ, Gough AK, Devlin J, Smith J, Astin P, Taylor D, Emery P. (2003) Serum MMP-3 and MMP-1 and progression of joint damage in early rheumatoid arthritis. Rheumatology (Oxford)42 (1): 83-8. [PMID:12509618]

3. Ma D, Wu W, Yang G, Li J, Li J, Ye Q. (2004) Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors. Bioorg. Med. Chem. Lett.14 (1): 47-50. [PMID:14684295]

4. Nuti E, Casalini F, Santamaria S, Gabelloni P, Bendinelli S, Da Pozzo E, Costa B, Marinelli L, La Pietra V, Novellino E et al.. (2011) Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors. Eur J Med Chem46 (7): 2617-29. [PMID:21514700]

5. Wang YD, Mao JW. (2007) Expression of matrix metalloproteinase-1 and tumor necrosis factor-alpha in ulcerative colitis. World J. Gastroenterol.13 (44): 5926-32. [PMID:17990358]

How to cite this page

M10: Matrix metallopeptidase: MMP1. Last modified on 16/03/2017. Accessed on 22/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1628.