Target id: 1631

Nomenclature: MMP7

Family: M10: Matrix metallopeptidase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for MMP7 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 267 11q21-q22 MMP7 matrix metallopeptidase 7
Mouse - 267 9 A1 Mmp7 matrix metallopeptidase 7
Rat - 267 8q11 Mmp7 matrix metallopeptidase 7
Previous and Unofficial Names
matrin | PUMP-1 protease | uterine metalloproteinase | MPMM | MAT | MPSL1 | matrix metallopeptidase 7 (matrilysin, uterine)
Database Links
Specialist databases
MEROPS M10.008 (Hs)
Other databases
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
doxycycline Hs Inhibition 4.1 pKd 2
pKd 4.1 (Kd 7.3x10-5 M) [2]
SL422 Hs Inhibition 9.1 pKi 3
pKi 9.1 (Ki 8x10-10 M) [3]
RS 39066 Hs Inhibition 9.6 pIC50 1
pIC50 9.6 (IC50 2.3x10-10 M) [1]
Inhibitor Comments
SL422 is a broad-spectrum inhibitor of MMP enzymes [3].


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1. Chen JJ, Zhang Y, Hammond S, Dewdney N, Ho T, Lin X, Browner MF, Castelhano AL. (1996) Design, synthesis, activity, and structure of a novel class of matrix metalloproteinase inhibitors containing a heterocyclic P2′-P3′ amide bond isostere. Bioorganic & Medicinal Chemistry Letters, 6: 1601-1606.

2. García RA, Pantazatos DP, Gessner CR, Go KV, Woods Jr VL, Villarreal FJ. (2005) Molecular interactions between matrilysin and the matrix metalloproteinase inhibitor doxycycline investigated by deuterium exchange mass spectrometry. Mol. Pharmacol., 67 (4): 1128-36. [PMID:15665254]

3. Xue CB, Voss ME, Nelson DJ, Duan JJ, Cherney RJ, Jacobson IC, He X, Roderick J, Chen L, Corbett RL et al.. (2001) Design, synthesis, and structure-activity relationships of macrocyclic hydroxamic acids that inhibit tumor necrosis factor alpha release in vitro and in vivo. J. Med. Chem., 44 (16): 2636-60. [PMID:11472217]

How to cite this page

M10: Matrix metallopeptidase: MMP7. Last modified on 16/03/2017. Accessed on 18/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY,